Micb 202: Immunological Disorders

Front 1

Autoimmune hemolytic anemia: describe the traits and outcome.

Back 1

- make antibodies against RBCs
- complement proteins lyse antibody-coated RBCs
- less oxygen delivered to tissues

Front 2

Myasthenia gravis: describe the traits and outcome.

Back 2

- antibodies bind to acetylcholine receptors on muscle cells and prevent them from responding to neurotransmitter
- may result in paralysis

Front 3

Lupus: describe the traits and outcome.

Back 3

- antibodies against many self components
- kidney blockage

Front 4

Diabetes: describe the traits and outcome.

Back 4

- self-reactive Th1 cells
- inflammatory response due to cytokines
- tissue damage (destruction of pancreatic insulin-producing cells)

Front 5

SCID: describe the traits and outcome.

Back 5

- no functional B or T cells due to error in gene rearrangement
- massive infection results

Front 6

Immunoglobulin deficiency: describe the traits and outcome.

Back 6

- failure to make IgG or IgA
- recurrent infections

Front 7

Complement deficiency: describe the traits and outcome.

Back 7

- failure to make complement proteins
- recurrent bacterial infections

Front 8

AIDS: describe the traits and outcome.

Back 8

- HIV infects macrophages => T helper cells => virus hides inside cells
- loss of Th cells
- B cells cant make antibodies
- macrophages cannot kill intracellular bacteria
- opportunistic infections lead to death

Front 9

What was the old idea for AIDS treatment? What was the problem?

Back 9

targetting gp120 protein. it mutates too rapidly.

Front 10

What is the current AIDS treatment?

Back 10

reverse transcriptase blockers (AZT, ddI) + protease inhibitor

Front 11

What are the two new targets for AIDS treatment?

Back 11

targetting CCR5 and CXCR4 cytokines

Front 12

Why cant we target CD4 in the cure for AIDS?

Back 12

CD4 is needed for T cells to interact with APCs

Front 13

What is the first cell that HIV infects?

Back 13

macrophages

Front 14

Are our antibodies effective against HIV? Why / why not?

Back 14

No. The virus hides inside cells.