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18 Cards in this Set

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TNF
Source: Macs and T cells
Action:
1) Inflammation
2) activates neutrophils
3) Cause leukocytes to enter damaged tissue
3) excess leads to septic shock.
IL-1
Source: Macs and endothelial cells
Action:
1) Inflamation
2) Causes leukocytes to enter damaged tissue
IL-12
Source: Dendritic Cells and Macs
Target: NK cells and T cells
Action:
1) Causes Nks and Ts to secrete INF-gama
2) Causes TH1 differentiation to effector cells
INF-gama
Source: Nks and T cells
Target: Macs
Action: Activates macs. Stimulates some antibody response.
Type 1 IFNs
Source: dendritic cells, macs, and fibroblasts
Action:
1) All cells go into anti viral state and ^ MHC 1 expression
2) Activates NKs
IL-10
Source: Macs, dendritic cells, T cells
Targets: Macs and dendritic cells
Action: Inhibits IL-12 production reducing expression of costims and class 2 MHCs.
IL-6
Source: Macs, endothelial cells, T cells
Target: B cells
Action: Causes proliferation of plasma cells
IL-15
Source: Macs
Action: NK and T cell prolif.
TGF-Beta
Source: Many cells
Action:
1) Inhibits inflamation
2) Turns T cells to T regs.
NF-KB
Transcription Factor activated by TLRs. Promotes expression of various cytokines and endothelial adhesion molecules.
IRF-3
Important transcription factor activated by TLRs. Stimulates production of type 1 interferons.
IL-7
Maintains and expands the # of lymphocyte progenitors before they express antigen progenitors. Also helps keep memory cells alive.
IL-2
Source: CD4 (some CD8s)
Action: Causes T cell proliferation (sometimes called t cell growth factor)
IL-4
Source: CD4s and mast cells
Action: causes isotype switching of Bs to IgE
IL-5
Source: CD4s and mast cells
Action: Activates eosinophils.
DAF
Decay accelerating factor. Found on mammalian membranes. Goes next to CB3 and prevents all other components from interacting with it. Stops classical and alternative compliment pathway.
C1 INF
Binds to R and S of C1 molecule preventing its formation. Blocks classical pathway.
IL-10
When a CD4 decides to become a TH2, IL-10 secretion inhibits TH1 response.