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14 Cards in this Set

  • Front
  • Back

Described as an amphibolic pathway because...

It has catabolic and anabolic functions

Electron carriers involved in TCA cycle?


Reactive part of NAD?

Nicotinamide ring

Reactive part of FAD?

Isoalloxazine ring

Where does the TCA cycle take place?

mitochondrial matrix

Yield from 1Acetyl CoA?

10 ATP

Rate of TCA cycle corresponds to..?

Rate of ETC

Which reactions regulate the TCA cycle?

-Citrate Synthase

-Isocitrate DH


-Malate DH

How does the Citrate Synthase reaction regulate TCA?

Increased [citrate]> decreased OA.

Enzyme switched off, Acetyl CoA diverted

How does ICDH reaction regulate TCA?

-Rate limiting step

-Increased ATP + NADH switch off

-Increased ADP and Ca2+ switch on

How does aKGDH reaction regulate TCA?

-Succinyl CoA is a competitive inhibitor

-NADH is a -ve allosteric effector

-Increased GTP inhibits

-Increased Ca2+ switches on - 2ndmes

Control of TCA cycle

Mainly dependent on O2 availability

Why is fluoroacetate toxic?

Binds to aconitase

inhibits the enzyme

blocks isocitrate formation

How does malonate block TCA cycle?

A 3C homologue of succinate

Able to bind with malate DH - competitive inhibitor

Causes build up of succinate, citrate and aKG