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8 Cards in this Set
- Front
- Back
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What is the formula for the partition coefficient?
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P = [drug] <--organic
----------------- [drug] <--aqueous |
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T/F: Most drugs have a partition coeffeicient
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True
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Define Partition coefficient
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A measure of the drugs lipid and water solubility (balanced in most drugs)
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__________ is determine by charges (polarity).
(hydrophilicity, hydrophobicity, lipophilicity or lipophobicity?) |
hydrophilicity
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What are the main two things that effect water solubility?
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-H bonding capacity
-Ionic character |
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Compounds with what two atoms have increased solubility?
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Nitrogen and Oxygen
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_______________ is increased by non-ionizable groups, hydrocarbon chains and ring systems.
(hydrophilicity, hydrophobicity, lipophilicity or lipophobicity?) |
Lipophilicity
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List side groups that can increase lipophilicity.
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-Non-ionizable groups
-Hydrocarbon chains -Ring systems (ex:benzyne) |
