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16 Cards in this Set
- Front
- Back
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Hansch π value for:
ketone/aldehyde |
-0.3
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Hansch π value for:
amide |
-0.7
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Hansch π value for:
alliphatic |
0.5
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Hansch π value for:
phenol |
2
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Hansch π value for:
alkenyl carbon |
.33
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Hansch π value for:
OH |
-?
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E(max)
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1/intercept, must be positive
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K(d)
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Dissociation constant; slope/intercept;
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Relative potency
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"antilog" d; "d" is distance (on chart) between the parallel lines of test drug and standard drug; d= log(dose)T/(dose)S
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ED(50)
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50% Effective Dose - the dose that produces the desired therapeutic effect in 50% of the treated population
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TD(50)
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50% Toxic Dose - the dose that produces death in 50% of the treated population
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T.I.
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Therapeutic Index = TD(50)/ED(50) = LD(50)/ED/50)
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When is T.I. misleading?
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when the log-dose response curves for effectiveness and tosicity have different slopes
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Drug Safety Margin
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([LD1]/[ED99] - 1) x 100
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plotting E vs log(dose)
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sigmoidal curve
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plot 1/E vs 1/[D]
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y intercept is 1/E(max) and slope is K(d)/E(max)
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