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16 Cards in this Set

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Hansch π value for:

ketone/aldehyde
-0.3
Hansch π value for:

amide
-0.7
Hansch π value for:

alliphatic
0.5
Hansch π value for:

phenol
2
Hansch π value for:

alkenyl carbon
.33
Hansch π value for:

OH
-?
E(max)
1/intercept, must be positive
K(d)
Dissociation constant; slope/intercept;
Relative potency
"antilog" d; "d" is distance (on chart) between the parallel lines of test drug and standard drug; d= log(dose)T/(dose)S
ED(50)
50% Effective Dose - the dose that produces the desired therapeutic effect in 50% of the treated population
TD(50)
50% Toxic Dose - the dose that produces death in 50% of the treated population
T.I.
Therapeutic Index = TD(50)/ED(50) = LD(50)/ED/50)
When is T.I. misleading?
when the log-dose response curves for effectiveness and tosicity have different slopes
Drug Safety Margin
([LD1]/[ED99] - 1) x 100
plotting E vs log(dose)
sigmoidal curve
plot 1/E vs 1/[D]
y intercept is 1/E(max) and slope is K(d)/E(max)