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36 Cards in this Set
- Front
- Back
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Alirocumab Evolocumab |
Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Inhibition ➡️➡️ ⬇️ LDL |
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Niacin |
⬇️ Hepatic synthesis of VLDL |
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Fibrates: (Fenofibrate, Gemfibrozil) |
Activates Peroxisome Proliferator receptor alpha (PPARa) ➡️➡️ ⬇️VLDL ➡️➡️ ⬇️ Triglycerides |
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Bile acid sequestrants |
Cholestyramine, Colesevelam, Colestipol Binds Bile acids in intestine➡️➡️ Preventing absorption of Bile acids ➡️➡️ ⬇️LDL |
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Ezetimibe |
inhibits absorption of cholesterol in small intestine➡️➡️ ⬇️LDL, TG |
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Statins |
(Pita, Rosu, Ator, Sim, Lo, Pra, Flu) Inhibit (HMG-CoA) reductase ➡️➡️ ⬇️LDL, TG ⬆️HDL |
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Lomitapide |
Inhibit Microsomal triglyceride transfer Protein (MTP) in the endoplasmic reticulum➡️➡️ ⬇️ Chylomicrons, VLDL, LDL |
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Mipomersen |
Oligonucleotide Inhibitor of apoB-100 synthesis ➡️➡️ ⬇️LDL |
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Thiazides |
Inhibit Na reabsorption in the distal convoluted tubules➡️➡️ ⬆️ excretion of Na, Cl, water |
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Dihydropyridine CCBs |
Inhibit Ca ions from entering vascular smooth muscles ➡️➡️ Perepheral arterial Vasodilation ➡️➡️ ⬇️ SVR/BP |
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Non-DHP CCBs |
Inhibit Ca ions from entering vascular smooth muscle (more selective for myocardium than DHP CCBs ➡️➡️ -ve inotroptic (ventricular contractions) and -ve chronotropic (HR) effects |
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ACE Inh. |
Block conversion of angiotensin I to angiotensin II ➡️➡️ ⬇️ Vasoconstriction+aldosterone secretion |
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ARBs |
Block Angiotensin II ➡️➡️ prevent vasoconstriction |
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K-sparing diuretics |
non selective blocking of aldosterone receptor (eplerenone-selective) |
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Aliskiren |
Renin inhibitor |
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Clonidine, Guanfacine, Methyldopa |
Centrally-acting a-2 adrenergic agonist ➡️➡️ ⬇️BP |
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Hydralazine, Minoxidil |
Direct Vasodilation of arterioles ➡️➡️ ⬇️SVR, BP |
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Digoxin |
Inhibit Na/K ATPase pump➡️➡️ ⬆️inotropic effect |
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Vilazodone |
SSRI and 5-HT1A partial agonist |
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Vortioxetine |
SSRI, 5-HT Antagonist, 5-HT1A Agonist |
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Bupropion |
Dopamina & NE Reuptake inhibitor |
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Tricyclics |
NE and 5HT Reuptake inhibitors Block ACh & Histamine |
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Benzodiazepines, Valproic acid, Phenobarbital, Primidone |
GABA agonist |
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Phenytoin/ Fosphenytoin Lamotrigine Carbamazepine/ Oxcarbazepine |
Na channel blocker |
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Unfractioned Heparin |
Binds to Antithrombin ➡️➡️ inactivates thrombin & Factor Xa ➡️➡️ prevents conversion of Fibrinogen to fibrin |
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Enoxaparin |
Binds to AT ➡️➡️ Inhibits more Factor Xa than Factor 2a |
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Dabigatran Argatroban Bivalirudin Desirudin |
Directly inhibit Thrombin (factor 2a) |
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Metoclopramide |
Dopamine antagonist ➡️➡️ Accelerate gastric emptying and enhance motility |
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Alvimopan |
Perepherally-acting Mu-opioid receptor antagonist |
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PDE-5 Inh |
⬆cGMP️➡️➡️ ⬆️blood flow to the penis |
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Class Ia Antiarrythmics |
Block Na & K channels |
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Ic Antiarrythmics |
Na Channel blockers |
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Class III Antiarrythmics |
Blockade of K channels |
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Sotalol |
Non-selective B Blocker |
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Cinacalcet |
⬆️ Sensitivity of Ca receptors on the parathyroid gland ➡️➡️ ⬇️ Ca, PTH, PO4 |
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Vit D Analogues |
⬆️ intestinal absorption of Ca ➡️➡️ -ve feedback to PTH |
