Md3 Block1 Pharmacology Antihistimines Part One Part A

Front 1

(I) Pharmacological effects of Histamine.

Back 1

.

Front 2

(ii) Histamine Site of action

Back 2

.

Front 3

(iii) Conditions which cause release Histamine

Back 3

.

Front 4

• (iv) diagnostic uses of Histamine

Back 4

• Allergic rhinitis (common cold)
• Allergic conjunctivitis (pink eye)
• Allergic dermatological conditions
• Urticaria (hives)
• Angioedema (swelling of the skin)
• Pruritus (atopic dermatitis, insect bites)
• Anaphylactic reactions (severe allergies)
• Nausea & vomiting (First generation H1-antihistamines)
• Sedation (First generation H1-antihistamines) .

Front 5

Anti histaminergic Rx-s acting at the H1 and h2 receptors

Back 5

True antihistamines are only the agents that produce a therapeutic effect that is mediated by negative modulation of histamine receptors (other agents may have antihistaminergic action but are not true antihistamines)

Front 6

(iv) diagnostic uses of Histamine

Back 6

.

Front 7

The term antihistamine only refers to

Back 7

H1 receptor antagonists (actually inverse agonists)

Front 8

Antihistamines compete with histamine for binding sites at the receptors. Antihistamine cannot

Back 8

remove the histamine if it is already bound

Front 9

Anti histaminergic Rx-s acting at the H1 and h2 receptors Know pharmacological effects

Back 9

.

Front 10

Anti histaminergic Rx-s acting at the H1 and h2 receptors Understand mechanisms of action

Back 10

.

Front 11

Be able to list therapeutic uses of antihistaminergic Rx-s

Back 11

.

Front 12

Be able to describe side effects and Rx interactions

Back 12

.

Front 13

Be familiar with the existence of the H3 receptors

Back 13

.

Front 14

main mechanisms of action of Chromolyn Sodium

Back 14

.

Front 15

Chromolyn Sodium clinical applications.

Back 15

.

Front 16

Clinical significance of anti histaminergic Rx-s

Back 16

.

Front 17

What are Histamines; What causes allergies and what are they,

Back 17

.

Front 18

History of antihistaminergics

Back 18

.

Front 19

Classes of antihistaminergics

Back 19

.

Front 20

Future of anti histaminergic Rx-s and treatment of allergies in general.

Back 20

.

Front 21

Definition of allergies according to American Academy of Asthma, Allergies, and Immunology.

Back 21

.

Front 22

Synthesis of Histamine

Back 22

.

Front 23

Histamine (H1-4) receptors

Back 23

.

Front 24

Histamine (H1-4) receptors
(I) Location
(ii) Type of receptors
(iii) Pharmacological effects
(iv) Treatment

Back 24

.

Front 25

Clinical applications of antihistaminic agents

Back 25

.