Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
30 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
Refers to drug biotransformation metabolism that takes place in tissues other than the liver |
Extrahepatic metabolism |
|
|
|
The most common sites of extrahepatic metabolism include the ____ |
Portals of entry and exit of excretion |
|
|
|
5 extrahepatic sites |
Plasma Intestinal mucosa Intestinal bacterial flora Stomach Nasal mucosa |
PIISN |
|
|
Main purpose of plasma |
Activate prodrugs |
|
|
|
The plasma contains ____ which is responsible primarily for the ____ |
Esterase enzymes Hydrolysis of esters |
|
|
|
2 examples of simple esters |
Procaine Succinylcholine |
PS |
|
|
Use of succinylcholine |
Neuromuscular blocking agent |
|
|
|
2 main purpose of intestinal mucosa |
Site of absorption Site of metabolism |
SS |
|
|
Secrete a number of enzymes capable of metabolizing drugs and other xenobiotics |
Intestinal bacterial flora |
|
|
|
2 enzymes secrete by the intestinal bacterial flora |
Beta-glucoronidase enzyme Azoreductase enzyme |
BA |
|
|
2 functions of bacterial flora |
Convert vitamin precursor to their active forms Convert substances to their toxic form |
CC |
|
|
9 vitamins that can be converted by the bacterial flora (5) |
K B7 B12 B9 B3 |
KBB BB |
|
|
9 vitamins that can be converted by bacterial flora (4) |
B5 B1 B2 B6 |
|
|
|
2 other names of vitamin K |
Phytonadione Menaquinone |
PM |
|
|
Vitamin B7 |
Biotin |
|
|
|
Vitamin B12 |
Cobalamin |
|
|
|
Vitamin B9 |
Folate |
|
|
|
Vitamin B3 |
Nicotinic acid |
|
|
|
Vitamin B5 |
Panthotenic acid |
|
|
|
Vitamin B1 |
Thiamine |
|
|
|
Vitamin B2 |
Riboflavin |
|
|
|
Vitamin B6 |
Pyridoxine |
|
|
|
Precursor of Thiamine |
Thiamine diphosphate |
|
|
|
2 precursor of riboflavin |
Flavin mononucleotide Flavin adenine dinucleotide |
FF |
|
|
Precursor of pyridoxine |
Pyridoxal phosphate |
|
|
|
2 precursor of biotin |
Alanine Pimeloyl CoA |
AP |
|
|
Precursor of cobalamine |
Uroporphyrinogen III |
|
|
|
Precursor of folate |
Dihydropteroic acid |
|
|
|
Precursor of nicotinic acid |
Tryptophan |
|
|
|
Precursor of panthotenic acid |
Coenzyme A |
|
