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37 Cards in this Set
- Front
- Back
- 3rd side (hint)
Microctyic anemia
Normal FE and TIBC, and FEP Hi Retic count; |
Thalassemia
HPSM, target cells ~ w/ what |
beta thal
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Microctyic anemia
Normal FE and TIBC Hi FEP, retic count nl or low; HA, lethargy, constipation |
Lead Poisining;
what's on x-ray; what level is of concern and what do you do? |
lead lines;
> 10, ? recheck - find out Lead > 10: level of concern; 20-24: determine source of lead, evaluate Fe status; 25-44: remove lead source: chelate |
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Microcytic anemia
Low serum FE, Hi TIBC |
Iron Defeiciency
- Diet, blood loss, menses, ulcer, varices, GI, malabsorption, pregnancy |
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Rare AD
ANC < 3000 (nl range 3,000-5000) Q 21 days, fever, x 1 week, then rises again stomatitis, oral/GI uclers, skin infx, PNA, sepsis |
congenital Neutropenia
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Loss of genes:
1 --> ? 2- 3- 4- |
Hgb H: Loss of genes:
1 → SILENT carrier, ‘ 2→ mild alpha thal 3→ Hemoglobin H 4→ Hemoglobin Barts/incompatible w/ life |
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< 4 yo, > URI/AGE; what bug ~ with
- pale,; HGB 5-9; anemic -HPSM, vomiting, abd pain, bloody diarrhea; dehydration |
~ E.coli 0157:H7 (meat/pools); HUS
-Labs: Low plt (vs HSP!!!- nl PLT) , Hi WBC, Nl clotting studies; -BURR/Helmet cells -what's treatment |
fluid/lytes/avoid anbtx
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define ANC
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WBC x % Neutrophils: Nl range: 3,000-5,000;
# < 3,000 = neutropenia |
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Physiol drop in HCt by month 2-3 (8-10 wks) ; even in premie
-what's cause? and treatment |
Anemia of NB: Low EPO production
no tx unless cardiovascular compromise |
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Hi Ferritin; but Low Fe;
Microcytic anemia or Nl MCV Low TIBC, hi ferritin |
Chronic illness: plenty of stored ron but not getting to BM
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> 6 mo, BF infants; or cow’s milk;
Low Fe ; low hgb (<6) ; HI FEP Low ferritin, Hi TIBC |
Iron def anemia,
what's common cause and peak? |
> 6 mo, BF infants; or cow’s milk;
Tx: Fe, cont until ferritin Nl (< 12 mo) pk: 6mo -3 y |
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hair on end”, HPSM, thick bones;
-deficiency of beta globin due to mutation in both beta globin gene |
Major: “beta Thal;
what's complx and tx |
Tx: chronic transfusion;
Complx: cholelithiasis, hemosiderosis (iron dep in heart, liver, pancreas) |
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Hi Hgb F, and S
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Sickle cell anemia
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What will decrease Fe absorption in small intestine
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Oxylates
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What’s best parameter to determine adequacy of Fe replacement therapy
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increase in ferritin
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what's nuclear remnan that, suggest functionoal asplenia, extra medullary hematopeoiesis or marrow replacement by malignancy
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Howell Jolly bodies:
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what are Heinz bodies and what's associated w/ it?
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aggregated Hgb ~ thalassemia, G6PD def
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Basophilic stippling? and ~
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aggregated ribosome’s ~ thallesemia, unstable HB, iron deficiency (lead poisoining
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what are Schistocytes and ~ with?
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fragmented cells/fibrin strands: microangiopathic hemolytic anemia (HUS/TTP, DIC)
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Macrocytic anemia w/ megaloblastic changes ~ with what?
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nuclear dysmaturity, hyperseg polys due to B12/folate deficiency
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What's cause of Macrocytic anemia w/o magalobalstic changes and ~ ?
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bone marrow failure syndromes: DBA, Fanconi’s, aplastic anemia, preleukemia-myelodysplastic; drugs, chronic liver diz, hypothyroidism
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What are Giant platelets and ~ ?
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reticulocytes, seen in peripheral destruction w/ subsequent marrow compensation
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PE: Hypotrophic thenar eminence, Absent thumbs
short ~ syndrome |
Fanconi’s
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Angular stomatitis
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Iron deficiency
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Triphalangeal thumbs, short
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DBA (thumb looks like 5th finger)
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Hyperpigmentation
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Fanconi’s
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Anemia @ 3-6 mo suggests ?
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hemoglobinapthy or thalessemia syndrome
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Hb F ~ which globin chains
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alpha2, gamma2
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what to watch out for for patients w/ chronic blood transfusions
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Iron overload, need to start chelation therapy to remove excess iron or will get hemosiderosis (buildup in liver) and hearts
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Alpha2, beta 2
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Hgb A, ? human
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Normal adult Hb
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Alpha2 delta 2
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A2
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Hi in Beta Thal
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Alpha2 gamma2
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F
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Major Hb in Fetal life
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Beta 4
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H
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ALPHA thal, unstable, non-functional
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Gamma4
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Bart’s
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Alpha Thal – NB period, unstable, nonfxnal
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O2 Dissociate curve LEFT shifting causes?
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Hb F, fetal life, alkalosis, low 2,3 DPG
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O2 Dissociate curve RIGHT shifting causes?
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Acidosis (Bohr effect), hypoxia: HI 2,3 DPG, sepsis, hi altitude,
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? anemia Hi ferritin, Low Fe, Low TIBC
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Chronic Illness
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? anemia has Low ferritin, High TIBC
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Iron Deficiency
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