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20 Cards in this Set
- Front
- Back
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What age group is most likely to get ALL and what is the prognosis?
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children; good prognosis
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What age group is most likely to get AML and what is the prognosis?
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adults; not as good prognosis as ALL
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What finding on blood smear is diagnostic of AML?
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Auer rods, found in AML types M1-M3, most common in M3
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What cancer are smudge cells diagnostic of?
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CLL
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What is the age group most likely to get CLL?
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60+
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What cell markers give the best prognosis in ALL?
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CD10
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What are the common cell surface markers in CLL?
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Mature B cell markers: CD19 & CD20
CD5+ CD10- |
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What is the characteristic translocation of CML?
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t(9,22) forming Bcr-abl tyrosine kinase
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Which diseases are commonly Jak+?
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Polycythemia vera, agnogenic myeloid metaplasia, essential thrombocythemia
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How do you distinguish polycythemia vera from secondary polycythemia?
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Erythrocytosis in the setting of decreased epo.
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What is the classic cell finding in chronic idiopathic myelofibrosis?
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teardrop shaped erythrocyte
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What is a plasma cell disorder?
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neoplastic proliferation of well-differentiated immunoglobulins
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What is seen on a bone marrow biopsy from a patient with multiple myeloma?
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large often nucleolated neoplastic plasma cells filling the bone marrow
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What is found in the urine of patients with multiple myeloma?
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Bence-Jones protein, which is immunoglobulin light chain
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What are the major clinical findings in multiple myeloma?
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1. Severe bone pain & hypercalcemia
2. M protein spike on serum electrophoresis 3. Bence Jones proteinuria 4. Anemia 5. Increased susceptibility to infection 6. azotemia 7. Amyloidosis |
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Which enzyme activity is markedly reduced in CML leukemic lymphocytes?
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leukocyte alkaline phosphatase
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What is the characteristic cytogenetic finding in Follicular Lymphoma?
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t(14:18) increasing expression of BCL-2
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What are the cytogenetics of Burkitt Lymphoma?
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t(8;14) with increased expression of c-myc
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What is the characteristic histology of Burkitt lymphoma?
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lymph nodes with starry sky appearance
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What is the characteristic histology of Follicular Lymphoma?
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Lymph node with effacement of architecture by angular grooved cells in a nodular pattern
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