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17 Cards in this Set
- Front
- Back
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recognition
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B cell receptors bind to antigen, take in and digest antigen, then display epitopes on its MHC-II protein
-After costimulation by Th cell, divide repeatedly, differentiate into plasma cells, produce antibodies specific to that antigens atibodies |
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Attack
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antibodies bind to antigen, render it harmless, "tag it" for destruction
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antigens bind
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t specific complementary receptors
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Th cells bind
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to antigen presented on surface of B-Cell and releases interlukens
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plasma cells full of
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rough ER
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Humoral Immunity Process
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present > check >D.check >clone >turn into plasma or memory cells
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difference between humoral and cellular
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in humoral you dont need a macrophage, the B cell does it on its own.
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in humoral
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the end cell just releases a protein, the cell itself doesnt do anything
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antibody structure
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stem region-doesnt change
light/heavy chain changes through every protein |
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antibody diversity
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-immune system capable of as many as 1 Trillion different antibodies
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somatic recombination
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DNA segments shuffled and form new combinations of base sequences to produce antobody genes
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somatic hypermutation
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B cells in lymph nodules rapidly mutate creating new sequence
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humoral immunity
ATTACK |
Neutrolization
compliment fixation agglutination precipitation |
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neutrolization
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antibodies mask pathogenic region at antigen
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compliment fixation
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antigens bond to LgM or lgG, antibody changes shape, initiate complement binding; primary defense against foreign cells, bacteria
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Agglutination
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Antibody has 2-10 binding sites, binds to multiple enemy cells, immobilizing them
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Precipitation
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antibody binds antigen molecules (not cells) : create antigen-antibody complex that precipitates, phagocytized by eusonophils
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