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8 Cards in this Set

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What is the difference of self vs non-self?
Self=normal body tissues
Non-self= cells\molecules that immune system not exposed to during maturation
What is innate immune system and some of its components?
Immune cells and tissues in place before pathogen present

ie Macrophages, Tight junctions, complements, Granular cells
Can the innate immune system generate memory?
No memory is made, always same response time and efficiency
What are the 2 types of barrier defenses of the innate immune system?
Physical\ mechanical= TJ's, Mucous, tears, saliva

Microbial ie gut flora out competes foreign pathogens
How does surface epithelia contribute to innate immunity?
Tight junctions and

Chemical= acid secretion of stomach to anti bacterial NZ(lysozyme) to AntiBac peptides ie defensins(α and β)
What cells utilize alpha defensins?
alpha: in small intestine
neutrophils, NK cells

beta: most epithelial surfaces
What must bacteria do to infect a host?
Colonize or cross epithelial barrier
Is the response of the innate immune system specific? What types of things are recognized? using what receptor?
NO, very general response

LPS, mannose

PRR's- pattern recognition receptors