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20 Cards in this Set
- Front
- Back
Which of the following is NOT an activator of steps of glycolysis?
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Ac-CoA
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Moles which signal high cellular energy_____ glycolysis, whereas molecules which signal low cellular energy _____ glycolysis
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(High energy) inhibit; (low energy) activate
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Under cellular conditions, _____ steps of glycolysis have deltaG-actual = 0, meaning that they are at equilibrim
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7, step 1 short plateau step 2, long plateau 4-9, Downhill step = 1,3,10
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ATP is an immediate substrate in step 3 of glycolysis: F6P + ATP -> 1,6FBP + ADP. it also is a "long-range" ___ of that step
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product (and therefore feedback inhibitor)
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In Phosphofructokinase, ATP binds...
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Strongly to a C site & weakly to regulatory site
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The carbohydrates sucrose, lactose, mannose, glucose, and fructose all feed into reaction #2 or #3 of glycolysis because they all consist of...
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hexoses
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Many carbs feed into one of the components of the glycolysis series...
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F6P
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Synthesis of glucose-6-phosphate from glucose (Pi + Glc -> G6P) with nothing else involved is ___ . It is coupled to the reaction ___ , and the combination is favorable.
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Unfavorable; ATP & H2O-> ADP +Pi
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Which of the following is not AN INHIBITOR OF STEPS OF GLYCOLYSIS?
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Pi
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In the list below, the phosphate releasing reaction with the least favorable delta-G-nult is ___ .
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G6P -> Glc + Pi
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In the list below, the phosphate releasing reaction with the most favorable delta-G-nult is ___ .
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PEP -> pyruvate + Pi
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The most highly regulated step of glycolysis is step 3, since many hexoses feed into...
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F6P -> reactant of step 3
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The regulated steps of glycolysis have a delta-G-actual value which is...
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Strongly negative
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The enzyme kinetics curve for phosphofructokinase shows a peak at intermediate [ATP]. ATP binds as a substrate to a catalytic site and as an inhibitor to a regulatory site. The tighter binding is to the ___ site.
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Catalytic- The tighter (and therefore initial) binding is to the catalytic site, binding ATP as a substrate and leading to faster formation of product. The weaker (and therefore final binding at high [ATP]) is at the regulatory site, shutting down catalysis by long-range allosteric effects.
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Phosphofructokinase catalyzes step 3 of glycolysis: F6P+ATP -> 1,6 F6P + ADP. A plot of V-init vs ATP shows a velocity which____ as ATP increases
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increases at first and then decreases
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Step 10 of glycolysis is PEP + ADP -> ATP + pyr. Synthesis of ATP is an unfavorable factor, but this is paid for by ___ .
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enol -> keto tautomerization
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Step 6 of glycolysis is G3P(aldehyde) + Pi + (NAD+) -> 1,3BPG(carboylic acid derivative) + NADH. Since NADH has enough energy to make 3 ATP, creation of NADH is highly unfavorable. Synthesis of NADH is paid for by...
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oxidation of an aldehyde to a carboxylic acid (derivative)
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Step 6 of glycolysis is G3P(aldehyde) + Pi + (NAD+) -> 1,3BPG(carboxyl derivative) + NADH. The unfavorable factor(s) in this reaction include :
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Attachment of happy Pi to an organic molecule and formation of NADH
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Step 7 of glycolysis is 1,3BPG + ADP -> 3PG + ATP. Synthesis of ATP is an unfavorable factor by this is paid for by...
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Creation of a resonance-stabilized ionized COO- group
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Of the 10 steps of glycolysis, _____ are also used in gluconeogneeis
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7 - The three regulated steps with large negative delta-G-actual values also have large delta-G-nult values. Thus if they were allowed to proceed to equilibrium, they would lie far to the right (glucose -> pyruvate) and would not be appropriate for gluconeogenesis (which requires moving molecules to the left).
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