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41 Cards in this Set

  • Front
  • Back

Cornea

refracts light to project image onto retina

Lens

helps refract light, focus image on retina

Go over steps of visual processing

use slides

Two main portions of the retina

nasal fields and temporal fields

Nasal fields



interior of the retina, closer to nose, projects contralterally

Temporal fields

outer portion of retina, close to ears, projects ipsilaterally

Three layers of retina

1) photoreceptors - rod and cones




2) intermediate neurons




3) optic nerve fibers

Photoreceptors

rods and cones

Rod

no color, dim light, outside fovea, low acuity




Do not fire AP

Cone

color, bright light, inside fovea, high acuity



Do not fire AP




Each cone has one of three classes of pigments, with each responding a a range of wavelengths


Retina

where visual processing begins, has three layers, contains ~100 million photoreceptors, visual system updates ~ 3 times/sec based on photorecptor activity

Visual processing from the retina in terms of projections

Rod and cones project to bipolar cells which project to ganglion cells whose axons form the optic nerve. There are also intermediate neurons that provide more processing through lateral inhibition.


Horizontal cells - by the photoreceptor/bipolar synapse




Amacrine cells - by the ganglion synapse

Bipolar cells

Receive projections from the rod/cones.




Do not fire AP

Ganglion cells

receive projections from the bipolar cells, and conduct AP, make up the optic nerve

Acuity

Sharpness of vision



Great in the middle of the visual field, but falls off towards the perihpery



Highest in fovea


Fovea

central part of visual field; directly behind the pupil so there is less blood in front of it, therefore more light reaches it.



Contains the highest density of cones



SO: this is area of highest acuity

Rhodopsin

a photopigment that captures photons, selectively, at different wavelengths.



Two parts: retinal and opsin




Different cones captures different colors of light


visible light of spectrum is between

400 - 700 nm

UV light spec

less than 400 nm

Infrared light spec

greater than 700 nm

Light spec order from shortest to longest wavelenth

Gamma, Xray, UV, visible, infrared, radar, FM radio, TV, AM radio, AC circuits

Range of wavelength peaks in retina

420 nm for violet --> S cones


530 nm for green --> M cones


560 nm for yellow-green --> L cones


496 nm --> rods

Light's effect on retina

1) Under normal, no light condition, Na+ channels on photoreceptors are held open by cGMP.




2) Shine light, changing shape of retinal




3) rhodopsin dissociates into retinal and opsin -




4) opsin combines with and activates a g-protein called transducin (about 500 of these activated per rhodopsin)




4) Transducin activates phosphodiesterase




5) PDE converts cGMP to 5'-GMP (about 2000 cGMP per PDE




6) reduced cGMP causes Na+ channels to close




7) cell hyperpolarizes



In photoreceptors the brighter the light, the _______ the hyperpolarization

the greater

Photoreceptor layout

There is an inner segment and outer segment.




Outer segment = contains many discs, each containing many rhodopsin proteins




Inner segment = where hyperpolarity is measure, area where light passes first before reaching outer segement

Hyperpolarizing photoreceptors decreases________ release

glutamate. What effect this has depends on the bipolar cell/type of glutamate receptor maybe

Bipolar will be inhibited by light if it is ________

off-center/on-surround, where light in the center of the field inhibits the cells

Bipolar will be excited by light if it is ________

on-center/off-surround, where light in the center of the field excited the cells

Which cells in retina have receptive fields?

bipolar and ganglion

For on-center, If you illuminate the entire center...

you see a large depolariation in the bipolar cell




you see many AP in the ganglion cell

For on-center, If you illuminate the entire surround...

you see a large hyperpolarization in the bipolar cell




you see a drop/few AP in the ganglion cell

For on-center, If you illuminate the entire center and surround...

you see a small depolarization in bipolar cell



you see sporadic/normal AP in the ganglion cell


most axons from the optic nerve terminate on the....

lateral geniculate nucleus AKA visual thalamus

Pathway of visual processing

retina --> LGN --> Occipital cortex/visual cortex/prmary visual cortex/V1/striate cortex

Optic radiation

projections from the LGN to the PVC

extrastriate cortex

surrounding cortical regions are also critical for vision

Lateral geniculate nucleus

Cells here respond like retina, can also be activated by light




6 layers:




Magnocellular - 2 inner layers that contain larger cells, not for color vision




Parvocellular - 4 outer layers that contain smaller cells, for color vision




LGN cells have concentric fields (like retina)

Cells in the visual cortex respond to...

more complicated stimuli, like things moving in a certain direction

Magnocellular cells

Have relatively large receptive fields, 2 inner most layers, larger cells,




Input to here is from large ganglion M-cells




Do not respond to color





Parvocellular

Have relatively large receptive fields, 4 outer most layers, smaller cells,




Input to here is from small ganglion P-cells, that get input from cones




Do respond to color

Primary Visual cortex/visual cortex/occipital cortex/V1

Not very sensitive to light, need more specific stimuli




About 50% of V1 is dedicated to the fovea