Lecture 1 Introduction To Immunology

Front 1

define immunological tolerance

Back 1

inactivity against self

Front 2

2 branches of adaptive immunity

Back 2

cell mediated and antibody mediated

Front 3

what is immunopathology

Back 3

pathology caused not by the infectious agent but the immune response to that agent

Front 4

Where are immune responses initiated

Back 4

within lymphoid tissue (nodes and spleen)

Front 5

what form of infection will see a response primarily from within the spleen

Back 5

system infection (eg septicaemia)

Front 6

where are foetal blood cells produced

Back 6

foetal liver

Front 7

what 3 cell types are granulocytes

Back 7

neutrophils, basophils and eosinophils

Front 8

key role of neutrophils

Back 8

innate immunity and acute inflammation

Front 9

role of eosinophils

Back 9

parasitic infections

Front 10

features of a monocyte and it's role

Back 10

no cytoplasmic granules, no segmented nucleus, differentiates into macrophage at tissue infiltration

Front 11

mast cells are most similar to what granulocyte

Back 11

basophil

Front 12

dendritic cells develop from the same lineage as which myocyte

Back 12

macrophage (monocyte lineage)

Front 13

4 types of cell coming from the lymphoid progenitor

Back 13

NK cell, B cell and CD8 and CD4 T cells

Front 14

within lymph nodes where are T cells found

Back 14

central paracortex

Front 15

within lymph nodes where are B cells found

Back 15

outer cortex

Front 16

What are germinal centres

Back 16

During immune activation B cell follicles with in LN expand to become germinal centres.

Front 17

in what LN region are APC dendritic cells found

Back 17

within the paracortex (T cell area)

Front 18

where are acute phase proteins produced and what do they do

Back 18

Liver and tissue macrophages, mediate immune and inflammatory responses

Front 19

2 examples of APP and function

Back 19

C reactive protein (trauma, opsonises bacteria)), serum amyloid A (recruits immune cells to area)

Front 20

function of cytokines

Back 20

cell messenger molecules.

Front 21

5 classes of cytokine

Back 21

IL's, TGF's, TNF's, IFN's, CSF's