Lecture 1 #1

Front 1

Griffith's experiments:

Back 1

demonstrated the transforming principle

Front 2

Avery, McCloud, and McCarty:

Back 2

showed that the transforming principle was DNA

Front 3

The experiments of Hershey and Chase:

Back 3

used radioactive phosphorus to label DNA and radioactive sulfur to label proteins

Front 4

Why can't nucleic acids and proteins be distinguished from each other by labeling nitrogen with the 15N isotope?

Back 4

Nitrogen is found in both nucleic acids and proteins.

Front 5

Nucleic acids are longs chains of ________.

Back 5

nucleotides

Front 6

Which follows the complementary base pair rule?

Back 6

A-T, G-C

Front 7

The experiments of ________ showed that a bacterial phage labeled with 35S did not enter the bacteria, eliminating protein as the hereditary material.

Back 7

Hershey and Chase

Front 8

In Watson and Crick's model, the two strands of DNA in the double helix are held together by ________.

Back 8

hydrogen bonds

Front 9

Two strands of DNA that can form a double helix are said to be ________.

Back 9

complementary

Front 10

During DNA replication what determines the sequence of the bases in the new DNA strand?

Back 10

sequence of bases in the template strand

Front 11

The semi-conservative model of DNA replication proposed that:

Back 11

Each new DNA molecule contains one old strand and one new strand.

Front 12

Which of the following statements is not true?

a. Nucleotides are added to the 5' end of a growing chain of DNA.

b. The sliding clamp holds the DNA polymerase to the template.

c. DNA replication starts at the origin of replication.

d. Helicase unwinds the DNA.

e. DNA replication is semi-conservative.

Back 12

a. Nucleotides are added to the 5' end of a growing chain of DNA.

Front 13

During replication DNA is unwound by ________.

Back 13

helicase

Front 14

During DNA replication, the RNA primer is made by ________.

Back 14

primase

Front 15

Okazaki fragments are synthesized on ________.

Back 15

the lagging strand

Front 16

In DNA replication, which enzyme can proofread and correct mistakes?

Back 16

DNA polymerase

Front 17

Mutations:

Back 17

are base changes in the DNA

Front 18

Nucleosomes consist of ________ and special chromosomal proteins called ________.

Back 18

DNA, histones

Front 19

The loosely packed regions of chromosomes are known as ________.

Back 19

euchromatin

Front 20

The buffering regions near the ends of eukaryotic chromosomes are called ________.

Back 20

telomeres