Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
41 Cards in this Set
- Front
- Back
Clinical uses of Pilocarpine
|
Sjogren's and glaucoma
|
|
Edrophonium
|
alcohol, very short acting, 5-15 minutes, poorly lipid soluble
|
|
Drugs used in Myastenia Gravis
|
Edrophonium, Neostigmine, Pyridostigmine
|
|
Neostigmine
|
PO, 30 min-2hrs
|
|
Physostigmine
|
30 min-2 hours PO, Is lipid soluble
|
|
Parathion
|
very toxic, organophosphate, in pesticides
|
|
Clinical uses of Methscapolamine
|
GI and GU
|
|
Clinical use of Oxylbuthin
|
GU
|
|
Clinical use of Tolteradine
|
GU
|
|
Signs of Muscarinic Toxicity
|
Mad as a hatter, red as a beat
Can't see, can't pee, ... |
|
Ephedrine
|
a1a2b1b2
mixed |
|
oxymetazoline
|
nonselective alpha1 alpha2
|
|
Epinephrine
|
a1a2b1b2
|
|
mechanism of action of reserpine
|
blocking uptake of endogenous
|
|
mech of action of Guanethidine
|
competes with catecholamines for uptake; displaces Norepi from vesiicles
|
|
Name some direct acting adrenergic agonist?
|
PECTIN
Phenylephrine Epinephrine Clonidine Terbutaline Isoproterenol Norepinephrine Remember: Dobutamine |
|
Name some non-selective direct acting adrenergic agonist?
|
Isoproterenol
Epinephrine Norepinephrine |
|
What are the types of Indirect- acting Adrenergic Agonists?
|
Releasing agents
Uptake Inhibitors MAO/COMT Inhibitors |
|
What are the types of Indirect-acting Adrenergic Agonist
|
Releasing agents, Uptake Inhibitors, MAO/COMT Inhibitors
|
|
Direct-acting, mixed-acting, and indirect acting are all types of ______ agonist
|
Adrenergic
|
|
How does prior treatment with reserpine or guanethidine affect the releasing agents, amphetamine and tyramine?
|
Responses are Abolished
|
|
Hoe does prior treatment with reserpine or guanethidine affect the mixed- acting agent, ephedrine?
|
Response is REDUCED
|
|
How does prior treatment with reserpine or guanethidine affect the direct-acting adrenergic agonist?
|
Responses are NOT reduced
|
|
sympathomimetic describe primarily _________ activation which is due to a drug substance binding the same receptors as ______, and acting as an ______.
|
adrenergic
Norepinephrine agonist |
|
____________ are valuable therapy for myastenia patients
|
cholinesterase inhibitors
|
|
__________ is sometimes used as a diagnostic test for myasthenia.
|
Edrophonium
|
|
After a patient with myastenia gravis is given Edrophonium, how will muscle strength changes?
|
an improvement in muscle strength that lasts about 5 minuutes is usually observed.
|
|
myasthenic crises must be distinguished from ___ ______
|
cholinergic crisis
|
|
Long term therapy for myasthemia gravis is accomplished with _______, ____________, or __________
|
neostigmine
pyridostigmine ambenonium |
|
Drugs used in the treatment of pheochromocytoma.
|
phenoxybenzamine
phentolamine |
|
_______ receptor antagonist are most useful in the preoperative mangaement of patient with pheochromocytoma
|
alpha
|
|
Where is the tumor of pheochromocytoma found?
|
adrenal medulla
|
|
The tumor of pheochromocytoma releases a mixture of
|
epinephrine
norepinephrine |
|
Uses of Bethanechol
|
Post-op and Neurogenic Ileus and Urinary Retention
|
|
Uses of Carbachol
|
Glaucoma
|
|
Uses of Pilocarpine
|
Glaucoma
Sjogren's Syndrome |
|
Uses of nicotine
|
Smoking deterrence
|
|
Muscarinic Toxicity
|
CNS stimulation
Miosis, spasm of accomodation Bronchoconstriction Increases GI and GU smooth muscle activity Increased secretory activity: sweat glands, airway, GI tract Vasodilation, reflex tachycardia |
|
Nicotinic toxicity
|
CNS stimulation, including convulsions followed by depression
ganglionic stimulation and block neuromuscular end plate depolarization leading to fasciculation and paralysis |
|
cholinergic toxicity mnuemonic
|
D-Diarrhea
U- Urination M- Miosis B- Bronchoconstriction B- Bradycardia E- Excitation L- Lacrimation S-Salivation S-Sweating |
|
Agent used to treat insecticide poisoning. only agent available in the US
|
Pralidoxime
|