Knowmedge Internal Medicine Abim Exam Review Questions - Hematology

Front 1

What is the simplest test to differentiate anemia of chronic disease from iron deficiency?

Back 1

Total iron-binding capacity (TIBC)

Front 2

Along with homocysteine, what levels can be elevated with vitamin B12 deficiency?

Back 2

Methylmalonic acid levels

Front 3

Which antibody is associated with cold agglutinin hemolytic anemia?

Back 3

IgM

Front 4

Which vitamin is used to enhance iron absorption?

Back 4

Vitamin C (Ascorbic acid)

Front 5

Besides elevated MCV, what else can be elevated with folate deficiency?

Back 5

Homocysteine levels

Front 6

What environmental exposure can lead to acute vitamin B12 deficiency?

Back 6

Nitrous oxide

Front 7

Peripheral blood showing smudge cells is most specifically associated with what condition?

Back 7

Chronic Lymphocytic Leukemia (CLL)

Front 8

What hematologic condition is often associated with restless leg syndrome?

Back 8

Iron deficiency anemia

Front 9

Name three conditions that are very often associated with hypogammaglobulinemia

Back 9

CLL, nephrotic syndrome, bronchiectasis

Front 10

What mutation is often associated with polycythemia vera?

Back 10

JAK2 mutation

Front 11

Which two CD markers are often deficient in individuals with paroxsysmal nocturnal hemoglobinuria? (PNH)

Back 11

CD55 and CD59

Front 12

What are the most common vitamin K dependent clotting factors?

Back 12

Factors II, VII, IX, and X

Front 13

What is the earliest lab value to increase after repleting iron in patients with iron deficiency anemia?

Back 13

Reticulocyte count

Front 14

Name the four main causes of microcytic anemia.

Back 14

Thalassemia, Iron deficiency, Anemia of chronic disease, Sideroblastic anemia (mnemonic TICS)

Front 15

Which type of anemia is a common complication of chronic lymphocytic leukemia?

Back 15

Warm agglutinin autoimmune hemolytic anemia

Front 16

What condition is often associated with hypersegmented neutrophils?

Back 16

Vitamin B12 deficiency

Front 17

Patient is found to have a Pelger-Huet anomaly and hyposegmented neutrophils. What condition does this patient likely have?

Back 17

Myelodysplastic syndrome

Front 18

Blister cells or bite cells on peripheral smear are most often seen with what condition?

Back 18

Glucose 6 phosphate dehydrogenase deficiency (G6PD)

Front 19

What hematological condition is caused by a membrane defect of spectrin deficiency?

Back 19

Hereditary spherocytosis