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8 Cards in this Set
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1) T or F: viruses are the smallest agents of infection
2) How big are they? 3) What kind of genetic info do they carry? How is it packaged? 4) How does multiplication occur? 5) How can viruses react to host genomes? 6) What happens to an integrated viral genome? |
1) T
2) 20-300 nm in diameter 3) RNA or DNA in a capsid (protective protein shell), may have an envelope containing lipid and protein 4) Only within host cells, separate synthesis, subsequent assembly of component parts 5) Can become latent or integrate their genomes into host cells 6) Replicated as part of host genome, transmitted to each daughter cell w/out production of infectious virus |
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1) How are viruses classified?
2) What is a virion? 3) What is a capsid? 4) What are capsomeres? |
1) Single/ds viral nucleic acids, DNA or RNA)
2) Complete infectious virus particle 3) Protein shell that protects nucleic acid genome 4) Individual protein units of the capsid |
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1) What is the purpose of a capsid?
2) What is a nucleocapsid? 3) What are peplomeres? |
1) Protect the viral genome from destruction in environment, control host range and cell tropism of naked viruses
2) Protein shell + nucleic acid 3) Protein spikes found in the envelope of some viruses |
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1) T or F: viruses have metabolic activity outside of living cells
2) Shape of nucleocapsids? 3) What do helical nucleocapsids look like? 4) What do icosahedral nucleocapsids look like? |
1) F
2) Characteristic symmetry, helical or icosahedral 3) Extended nucleic acid cavity w/ helically arranged proteins w/ outer lipid envelope 4) Condensed nucleic acids as central portion, can be enveloped or naked. |
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1) Exs of viruses with helical nucleocapsids?
2) Exs of viruses with icosahedral symmetry? |
1) Orthomyxoviruses, Paramyxoviruses, Rhabdoviruses
2) Parvovirus, Adenovirus, herpesvirus, Picornavirus |
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1) What are envelopes?
2) What are envelopes derived from? How are they acquired? 3) T or F: envelopes are rigid 4) Where are viral glycoproteins peplomeres found? And what is their role? |
1) Lipid containing structures surrounding some viral particles
2) Nuclear/plasma cell membranes acquired during viral maturation, usually when viral nucleocapsid buds through host's membrane 3) F 4) Viral outer envelope. Have viral attachment proteins (VAP) that mediate viral binding and entry into host cells. |
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1) What does + sense RNA do?
2) What does - sense RNA do? |
1) Serves directly as mRNA
2) Must use RNA polymerase to synthesize a complementary + strand to serve as mRNA |
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1) What dictates whether or not cells will be infected with viruses?
2) What are hemagglutinins? They are excellent ____ 3) Antibody to what glycoprotein is used to monitor the course of HIV infection? 4) What protein is used to determine HIV load in the blood? |
1) Viral proteins
2) Viral proteins that agglutinate RBCs. Excellent vaccine antigens. 3) gp120 4) Capsomere protein p24 |
