Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
80 Cards in this Set
- Front
- Back
What drugs are Ototoxic... Auditory? |
Loops (Ethacrynic Acid > Furosemide)
VANCOMYCIN Macrolides Cisplatin |
|
What drugs are Ototoxic... Vestibular?
|
Minocycline
|
|
What drugs are Ototoxic Auditory and Vestibular?
|
Aminoglycosides
|
|
What drugs are Ototoxic causing Tinnitus?
|
Quinidine/Quinine (cinchonism)
ASA (salicylism) |
|
What drugs are nephrotoxic?
|
Vancomycin
Aminoglycosides Amphothericin B Foscarnet (hypercalcemia) Cisplatin (minimized w/ Amifestine) Cyclosporine |
|
What drug causes causes SIADH?
|
Carbamazepine
Chlorpropamide |
|
What drug causes Nephrogenic DI?
|
Lithium
Demeclocycline |
|
What drug causes hemorrhagic cystitis?
|
Cylcophosphamide
|
|
How do you prevent hemorrhagic cystitis w/ cyclophosphamide?
|
MESNA
|
|
How do you minimize nephrotoxicity from Cisplatin?
|
Amifostine
|
|
What are the hepatotoxic drugs?
|
AMIODARONE
STATINS VALPROIC ACID (hepatitis) Felbamate Tolcapone TETRACYCLINE (in pregnancy) RIPE TB therapy (Rifampin, Isoniazid, Pyrazinamide) ACETAMINOPHEN |
|
What do you give to OD w/ ACETAMINOPHEN?
|
Acetylcysteine
|
|
What drugs cause Blood dyscrasias?
|
Carbamazepine
|
|
What drug causes Aplastic Anemia?
|
Felbamate
|
|
What drug causes agranulocytosis?
|
Clozapine
|
|
What drug causes aplastic anemia and is dose dependent and dose independent?
|
Chloramphenicol
|
|
What HIV medication causes Blood dyscrasias (anemia/bone marrow suppresion)?
|
Zidovudine
|
|
What anticoagulant produces thrombocytopenia?
|
Heparin
|
|
What drug causes thrombotic thromocytopenia, purpura or TPP?
|
Ticlopidine
|
|
Most Cancer chemotherapeutic drugs cause?
|
Blood Dyscrasias
|
|
What drugs cause pancreatitis?
|
Valproic Acid
Didanosine/Zalcitabine Sulindac Asparaginase |
|
What drug used for seizures causes pancreatitis?
|
Valproic Acid
|
|
What drug used for HIV cause pancreatitis?
|
Didanosine
Zalcitabine |
|
What NSAID causes pancreatitis?
|
Sulindac
|
|
What drug used for ALL causes pancreatitis?
|
Asparaginase
|
|
What drugs produce gingival hyperplasia?
|
Phenytoin
Nifedipine Cyclosporine |
|
What drugs cause SLE in SLOW acetylators?
|
Hydralazine
Isoniazid Procainamide |
|
Drugs w/ problems with Atypical Pseudocholinesterase?
|
Succinylcholine (prolongs the activity)
|
|
What drug causes malignant hyperthermia?
|
Halothane/SUX
|
|
What drug causes Hemolytic Anemia in G6PD deficiency?
|
Sulfonamide
Primaquine Quinidine |
|
What drugs cause disulfiram like reaction?
|
Metronidazole
Chlorpropamide Griseofulvin Cefamandole Cefotetan Cefoperazone |
|
What drug (combination) causes Serotonin Sx?
|
MAOIs, TCAs, SSRIs, Meperidine
|
|
What drug causes acute hypertensive crisis?
|
Non-Selective MAOIs + Tyramine
|
|
What are the non-selective MAOIs?
|
Phenelzine
Trancylpromine |
|
What contains Tyramine?
|
Aged Cheese
Red Wine |
|
What DDI (drug-drug interaction) causes decrease in B.P. and possible death?
|
Sildenafil + Nitroglycerin
|
|
What two drugs in anti-cancer therapy you should never mix?
|
6-MP (Azathioprine) + Allopurinol
precipitate gout |
|
DOC for Borrelia?
|
Doxycicline
|
|
DOC for Ricketssia?
|
Doxycycline
|
|
DOC for T. pallidum?
|
Penicillin G
|
|
DOC for gonorrhea?
|
Ceftriaxone
"Floxacins" |
|
DOC for Atypicals (Chlamydia, Mycoplasma)?
|
Doxycicline or
Macrolide |
|
DOC listeria?
|
Ampicillin
|
|
DOC Legionella?
|
Macrolide
|
|
DOC Step (Group A)?
|
Pen G [V]
|
|
DOC C. difficile?
|
Metronidazole
or Vancomycin |
|
DOC enterococcus?
|
Penicillin + AG (Aminoglucoside)
|
|
DOC P. areuginosa?
|
Ticarcillin + AG
|
|
DOC for T. pallidum but penicillin allergy?
|
Doxycicline
|
|
DOC N. gonorreah but Penicillin Allergy?
|
Floxacin
|
|
DOC for Listeria but penicillin allergy?
|
TMP-SMX
|
|
DOC Strep (Group A) but penicillin allergy?
|
Macrolide
|
|
DOC enterococcus but penicillin allergy?
|
Vacomycin + AG
|
|
DOC P. areuginosa but penicillin allergy?
|
Aztreonam
|
|
DOC Borrelia in Pregnancy or Child?
|
Amoxicillin
|
|
DOC Ricketssia in Pregnancy or Child?
|
Chloramphenicol
|
|
DOC N. gonorrhea in Pregnancy or Child?
|
Ceftriaxone
|
|
DOC atypicals [chlamydia, Mycoplasma] in Pregnancy or Child?
|
Macrolide
|
|
DOC P. areuginosa w penicillin allergy?
|
Aztreonam, AG, Floxacin
|
|
DOC for Borelia for a prenant woman?
|
Amoxicillin
|
|
DOC N. gonorrhea for a prenant woman?
|
Ceftriaxone
|
|
DOC Atypicals [Chlamydia, Mycoplasma] for a prenant woman?
|
Macrolide
|
|
DOC for Borrelia in Children?
|
Amoxicillin
|
|
DOC N. gonorrhea in Children?
|
Ceftriaxone
|
|
DOC Atypicals in Children?
|
Macrolides
|
|
What is the Serotonin Sx?
|
Hyperthermia
Rigidity Autonomic Instability Myoclonus Kind of like when having sex!!! |
|
What causes Serotonin Sx in w/ Meperidine?
|
Combination w/ MAOIs, TCAs
but it is a metabolite called normeperidine that acts like SSRI |
|
How do protease inhibitors work?
|
Inhibit Aspartate Protease
|
|
Name two protein inhibitors?
|
Indinavir
RitonAVIR gp120 gp41 |
|
What happens to Uric Acid at high does Aspirin?
|
UA stays in the lumen and is peed out = uricosuric
|
|
What happens to Uric acid w/ low dose Aspirin?
|
Transport of UA (Uric Acid) is blocked from the blood to the lumen so it causes hyperuricemia
Aspirin (low dose) blocks secretion of Uric Acid |
|
What drug protects patient from nephrotoxicity taking cisplatin?
|
Amifostine
|
|
What drug prevents cardiotoxicity w/ Doxorubicin?
|
Dexrazoxane
|
|
What drug prevents toxicity to epithelial, GI and bone marrow in Methotrexate high dose anti-cancer tx?
|
Leucovorin
restores purines |
|
Where does Aspirin work?
|
COX-1
Cycloxygenase 1 |
|
Where does abcximab work?
|
GP IIB/IIIA receptor on platelets. Can't join together
|
|
Where does ticlopidine work? (Clopidrogel)
|
Blocks ADP release
|
|
Where does propilthioracil and Methimazole work?
|
Peroxidase in thyroid synthessis
|
|
Where does Iodide (high dose) work?
|
blocks release of proteolytic T3 ---> T4
|
|
Where does Propilthioracil and Propanolol work?
|
inhibit deiodinase (liver) conversion of T4 to T3
|