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14 Cards in this Set
- Front
- Back
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What is jaundice |
Excessive amount of hemobilirubin or cholebilirubi in blood and tissue fluids causing yellow diascoloration |
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Types of jaundice |
Hemolytic - prehepatic Toxic - intrahepatic Obstructive - posthepatic |
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Causes of hemolytic jaundice |
Protozoa - piraplasmosis, babesiosis Clostridium hemolyticum bovis - causes Bacillary hemoglobinuria Hemolytic anemia - Rh nega mom makes antibodies againt Rh positive baby Incomplete blood typing |
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Causes of toxic j |
Salmonella Hepatitis Injured hepatic cells Plant toxins (seneco, crotalaria) Organic compounds (clay pigeons) |
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Causes obst. Jaundice |
Parasitez - Ascaris, Thysanosoma actinoides, Fasciola Tumors Cholangitis and cholecystis |
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Normal RBC breakdown |
Dead rbc > SPLEEN Heme (5%) , Iron, Globin (95%) Heme > porphyrin > Biliverdin > LIVER Biliverdin + liver albumin > hemobilirubin > hemobilirubin + glucoronic acid > cholebilirubin > passed through bile > INTESTINES Cholebilirubin > Urobilinogen > urobilin (poo) and stercobilin (pee) |
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Pathogenesis of hemolytic j |
Too much RBC death that the liver cannot absorb and metabolize it |
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Pathog. Of toxic j |
Hepotocyte necrosis which causes the cholebilirubin to escape through the hepatic cords and enters the sinusoids to adjacent organs |
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Pathog. Of obstructive j |
Cholebilirubin cant enter the intestines bc of biliary obstruction |
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Dx for jaundice |
Icteric index - plama color ( standard soln of potassium dichromate) Van Den Bergh rxn - Erlich's reagent w plasma or serum to make color reactiom |
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What do u call the colored compound in Van Den Bergh rxn |
Azorubin or azobilirubin |
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Interp of Van Den Berghs rxn |
Direct - 1-2 mins : Pink -purple (cholebilirubin) obstructive Indirect - 2 mins : no color, 10 mins : golden, 1hr : brown > pink (Hemobilirubin) hemolytic Biphasic - 2 mins : brown red (Chole and hemobilirubin) toxic |
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Describe the colors of hematoidin and hemosiderin |
Hematoidin - yellow and green Hemosiderin - brown (Fe) |
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Microscopic app of jaundice |
Heart failure cells Blue granules Hemosiderin granules |
