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25 Cards in this Set

  • Front
  • Back

Role of histology department

Produce accurate diagnostic information from patient tissue samples by studying thin slices of the tissue under the microscope



Many diseases produce predictable/typical structural changes that can be interpreted

Role of lab assistants

Book in samples


Order supplies

Role of biomedical scientist

Processing


Embedding


Sectioning


Staining


Quality control checks


Quality assurance



Advanced practitioners- can perform cut ups and report on some specimen grades

Role of pathologist

Initial cut up


Interpretation of results


Post mortem examinations


Secretarial staff

Enter patients on top the LMS


Transcribe the macroscopic descriptions

From sample to slide

Biopsy - fixation- transportation- booking in- tissue selection- macroscopic description-processing- embedding- microtomy- Staining- mounting- reporting- LMS entry

Excision biopsy

Complete removal of diseased tissue with a margin of healthy tissue

Sample adequacy

Tissue sample representative of disease states of all of the tissue


No false negatives when disease is present

What is quality management?

Ensuring all activities are carried out effectively and efficiently with respect to system and performance

Role of quality managers

Interpretation quality manager system and implement quality policy, objectives

Cells

Basic unit of structure

Tissues

Various cells combine to perform a specialised function

Organs

Comprised of different tissues that work cooperatively

Systems

Composed of organs that work cooperatively

4 basic types of tissue

Epithelial


Connective


Muscle


Nervous

Role of epithelial cells

Cover body surfaces, line body cavities and form glands


Avascular


Protection


Absorption


Filtration


Excretion


Secretion


Cells are in close proximity to each other and form sheets


They are polar- have an apical and basal surface


Regenerative capacity

Epithelial cell classification

According to microscopic shape and layering structure



Shape- squamous, cuboidal, Columnar


Layering- simple, pseudo stratified and stratified



Shape+ layering= type

Role of connective tissue

Provide physical support


Bind other structures together


Provide transport system (blood)


Provide insulation (fat)


Protection


Provide immune functions

Types of connective tissue

Loose - adipose and reticular


Dense- ligaments, elastic fibres


Cartilage- hyaline, elastic, fibrocartilage

Role of nervous tissue

Conduct electrical impulses


Complimented by various support cells


Found in brain, spinal cord and nerves

Nervous tissue supporting cells

Schwann cells form myelin around myelinated axons


Glial cells are the most numerous cells in the immune system


- oligodendroglia- form processes ending in myelin that wrap an axon segment


- Astroglia- star shaped cells interacting with capillaries and neurones


- microglia- macrophage function


- ependymal cells- line central cavities of brain and spinal cord

Role of muscle tissue

Highly vascularised tissue composed of elongated cells containing myofilaments actin and myosin



Three types - skeletal, cardiac and smooth

Skeletal muscles

Long cylindrical cells with visible striations


Multinucleate


Facilitate voluntary movement



Epimysium - covers outer surface of muscle


Penmysium- covers each fascicle


Endomysium- covers each fibre

Cardiac muscle

Formation wall of heart


Under autonomic control


Uninucleate


Short and thick


Branching cells form intercalated discs

Smooth muscle

Lines the walls of many organs


Contraction is under autonomic control


Elongated


Uninucleate


Non-striated


Transverse and longitudinal