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9 Cards in this Set
- Front
- Back
define preload
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End diastolic volume, amount of blood that enters during diastole and causes passive stretching of cardiac muscle
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define afterload
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pressure that the heart pumps against to eject blood (aortic P)
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define inotrope
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drug that alters strength of contraction of cardiac muscle (can be positive or negative)
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define lusitrope
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drug that alters relaxation of cardiac muscle (positive or negative)
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define chronotrope
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drug that alters rate of contraction of cardiac muscle (positive or negative)
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What is the mechanism of action for Digoxin?
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Na/K ATPase inhibitor
- positive inotrope because it allows Ca to enter the the cell via increased action of the Na/Ca exchanger |
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What is Digoxin used for?
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correcting atrial fibrillation (used to be used in heart failure, not so much anymore)
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What is the mechanism of action of Pimobendan?
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Phosphodiesterase III inhibitor
- positive inotrope, vasodilator (arterial and venous) by increasing levels of cAMP and increasing sensitivity of troponin C for Ca to enhance binding |
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What is Pimobendan used for?
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reduces afterload and preload, approved for use in dogs
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