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32 Cards in this Set
- Front
- Back
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Cyclosporine mech of action?
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binds to cyclophyilins. blocks differentiation and activation of t cells by inhibiting calcineurin
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clinical use for cyclsporine?
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suppress organ rejection after transplantation, some AI disorders
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toxicity for cyclosporine?
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nephrotox, HTN, hyperlipidemia, hyperglycemia, tremor, gingival hyperplasia, hirsutism
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tacrolimus mech of action?
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binds to FK-binding protein, inhibiting calcineurin and IL-2 secretions
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clinical use for tacrolimus?
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potent immunosuppression in organ transplants
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toxicity for tacrolimus?
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nephrotox, HTN, hyperlipidemia, tremor
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Sirolimus mech of action?
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inhibit mTOR. Inhibits t-cell proliferation in response to IL-2.
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Clinical use for sirolimus?
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immunosuppression after kidney transplant in combo with cyclosporine and corticosteroids.
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toxicity for sirolimus?
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hyperlipidemia, thrombocytopenia, keukopenia
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Azathioprine mech of action?
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antimetabolite precursor for 6-MP that interferes with metabolism and sythesis of nucleic acids. toxic to proliferatiing lymphocytes
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clinical use for azathioprine?
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kidney transplant, AI disorders
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toxicity for azathipprine?
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BM suppression. 6-MP metabolite metabolized by xanthine oxidase, so cannot use with allopurinol.
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Muromonab mech of action?
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mono Ab that binds to CD-3 on T-cells. blocks cell interations with CD-3 protein for t-cell transduction
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clinical use for muromonab?
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immunosuppression kidney transplant
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toxicity for muromonab?
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cytokine release syndrome, hypersensitivity reastion
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recombinant cytokine aldesleukin (IL-2) is used for?
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renal cell carcinoma, melanoma
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recombinant cytokine epoetin alfa (EPO) used for?
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anemias
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recombinant cytokine filgrastim (GCSF) used for?
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recover bone marrow
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recombinant cytokine sargramostin (GMCSF) used for?
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recover bone marrow
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recombinant cytokine a-interferon used for?
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Hep B and C, kaposi sarcoma, leukemias, melanmoa
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B-interferon used for?
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MS
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Y-interferon used for?
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chronic granulomatous dz
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Oprelvekin used for?
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thrombocytopenia
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thrombopoietin used for?
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thrombocytopenia
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muromonab used for?
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prevent transplant rejection
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digoxin immune Fab used for?
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antidote for dig tox
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infliximab used for?
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crohn's dz, rheumatoid arthritis, psoritic arthritis, ankylosing spondylitis
targets TNF |
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adalimumab used for?
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crohn's dz, RA, psoriatic arthritis
targets TNF-a |
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Abciximab used for?
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prevent cardiac ischemia in unstable angina
Targets GP 2b3a |
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Trastuzumab usd for?
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breast cancer expressing HER-2
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Rituximab used for?
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b-celll NHL
targets CD 20 |
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omalizumab used for?
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addtl. tx for asthma
targets IgE |
