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22 Cards in this Set
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- Back
- 3rd side (hint)
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cyclosporine
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binds to cyclophilins and blocks the differentiation and activation of T cells by inhibiting calcineurin preventing IL2 and IL2R production
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Use: suppress organ rejection, autoimmune dz
Toxicity: predisposes pts to viral infection and lymphoma, nephrotoxic (prevent with mannitol diuresis) |
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Tacrolimus (FK506)
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binds to FK binding protein and inhibits secretion of IL2
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Use: potent immunosuppressant for organ translplant
Toxicity: nephrotoxicity, peripheral neuropathy, hypertension, pleural effusion, hyperglycemia |
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Sirolimus (rapamycin)
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binds to TOR and inhibits T cell proliferation in response to IL2
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immunosuppression after kidney transplantation in combination with cyclosporine and corticosteroids
Toxicity: hyperlipidemia, thrombocytopenia, leukopenia |
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Daclizumab
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monoclonal Ab with high IL2R affinity
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Azathioprine
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antimetabolite precursor of 6-mercaptopurine (6MP) that interferes with synthesis of nucleic acids, toxic to proliferation lymphocytess
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Use: kidney transplant, autoimmue (glomerulonephritis and hemolytic anemia)
Toxicity: bone marrow suppression, metabolized by xanthina oxidase |
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Muromonab-CD3 (OKT3)
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monoclonal antibody that binds to CD3 on T cells and blocks signal transduction
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Use: immunosuppression following kidney transplant
Toxicity: cytokine release syndrome, hypersensitity reaction |
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Aldesleukin
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renal cell carcinoma, metastatic melanoma
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epotein
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anemias
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filgrastim (granulocyte stimulation factor)
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recovery of bone marrow
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sargramostim (granulocyte-macrophage colony factor)
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recovery of bone marrow
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beta interferon
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MS
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gamma interferon
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chronic granulomatous dz
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oprelvekin
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thrombocytopenia
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thrombopoietin
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thrombocytopenia
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muromonab-CD3
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against CD3
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prevent acute transplant rejection
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daclizumab
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IL2 receptor
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prevent acute renal transplant rejection
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digoxin immune fab
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against digoxin
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antidote for digoxin intoxication
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infliximab
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against TNF alpha
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chron's dz, RA, psoriatic arthritis
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abciximab
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gpIIB/IIIA
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prevent ischemia in unstable angina and in pts with percutaneous coronary intervention
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trastuzumab
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erb-B2
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her-2 overexpressing breast cancer
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rituximab
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against CD 20
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B cell NHL
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alpha interferon
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Hep B and C, Kaposi's sarcoma, leukemias, malignant melanoma
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