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19 Cards in this Set
- Front
- Back
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L-selectin
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- expressed on naive lymphocytes
- binds to countermolecule on High Endothelial Venule (HEV) EFFECT: Rolling Leukocyte |
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LFA-1 (CD11a & CD18) integrin
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- expressed on naive lymphocytes
- binds to ICAM-1 and ICAM-2 (on HEV) - LFA = lymphocyte function associated antigen EFFECT: Firm Adhesion |
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ICAM-1
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- expressed on HEV
- binds to LFA-1 (CD11a & CD18) integrin EFFECT: Firm Adhesion |
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P-selectin
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- Histamine induced
- on activated vascular endothelium - is stored in cytoplasm - binds to carbohydrate ligand EFFECT: Rolling Leukocyte |
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E-selectin
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- induced by TNF & IL-1
- requires de novo synthesis - binds to carbohydrate ligand - on activated vascular endothelium EFFECT: Rolling Leukocyte |
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VLA-4 (CD49d & CD29) integrin
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VLA-4 = Very Late Antigen 4
- on lymphocytes - binds to VCAM-1 - adaptive immunity response EFFECT: Firm Adhesion |
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VCAM-1
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- adhesion molecule on Endothelium
- induced by TNF and IL-1 - binds to VLA-4 EFFECT: Firm Adhesion VCAM = Vascular Cell Adhesion Molecule |
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PECAM
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- adhesion needed for transmigration
- PECAM is on both sides (leukocyte and endothelium) PECAM = Platelet Endothelial adhesion molecule. Constitutive on all vascular tissue |
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MAC-1 (CD11b & CD18)
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- on neutrophils
- binds to ICAM-1 (TNF & IL-1 induced) EFFECT: Firm Adhesion MAC-1 = Macrophage Antigen 1 |
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CD2
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- on T-cell
- binds to LFA-3 EFFECT: Adhesion |
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ICAM (1,2,3)
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- binds to LFA-1 (Cd11a & CD18)
- found on HEV and APC EFFECT: Firm Adhesion ICAM = Intracellular Adehesion Molecule |
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LFA-3
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- binds to Cd2
- on APC EFFECT: Adhesion |
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CD40L ( CD154)
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- Binds to CD40
- Found on T-Cell EFFECT: Isotype Switching (B cells) |
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CD40
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- Binds to CD40L (CD154)
- Found on APC EFFECT: Isotype Switching (B cells) |
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CD28
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- Binds to CD80 & CD86 (B7-1, B7-2)
- On T-cell EFFECT: Enhanced transcription of IL-2 - Stabilization of IL-2 mRNA - Costimulation |
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CD80 & CD86 (B7-1, B7-2)
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- Binds to CD80 & CD86 (B7-1, B7-2)
- On APC - dendrites most effective APC b/c have Cd80/CD86 constitutive; other APC need to induce EFFECT: Enhanced transcription of IL-2 - Stabilization of IL-2 mRNA - Costimulation |
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CD152 (CTLA-4)
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- Binds to CD80 & CD86 (B7-1/ B7-2)
- on T-cell EFFECT: Down regulation of T-cells CTLA-4 = Cytotoxic T-cell lymphocyte associated protein 4 |
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CD4
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- binds to MHC Class II
EFFECT: Costimulation |
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CD8
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- binds to MHC Class I
EFFECT: Costimulation |
