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30 Cards in this Set
- Front
- Back
IL-1 and IL-6 enhance expression of ___ and its receptors on T cells
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IL-2
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T-cells release ___ and ___ which cause B cells to divide + differentiate into antibody-forming cells and memory cells
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IL-6, IL-10
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TH1 secretes...
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IL-2 and IFN gamma
when THI activated - against pathogens (proliferation) |
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TH2 secretes...
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IL-4, IL-5, IL-6, IL-10,
when THII activated -stimulate B cells to proliferate/produce Abs (6+10 = differentiation) |
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CD refers to...
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cluster of antibodies that recognize a particular cell marker
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CD3 complex structure has a special feature which is ?
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external domain, transmembrane domain, cytoplasmic tail
* transmembrane domain contains neg. charged AA!! this brings receptor and CD3 together, because TCR transmemb domain (of alpha and beta chains) has a pos. charged AA |
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Ion pairs or hydrogen bonds form between ____residues in TCR and ____residues in CD3
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basic, acidic
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TCR1 found where?
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small # Tcells in thymus, secondary lymphoids, abundant in various epithelia
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The hypervariable regions of V domain of alpha-beta TCR come together to form___
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antigen binding site
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TCR2 distinguished by expression of __ or __
TCR2 CD4 classified by ___ secretion |
CD4/CD8
cytokine |
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B cells classified by ____
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surface immunoglobulins
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what 2 isotypes do Bcells in peripheral blood express on surface
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IgM, IgD
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Main markers used to identify human Bcells
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CD19, CD20, CD22
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NK cell recognized presence or absence of ___receptor to signal whether or not to kill
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MHCI
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___ direct lymphocyte trafficking
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HEV's - high endothelial venules
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lymphoid cells go back to mucosal tissue they came from by recognizing ___
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adhesion molecules on musocal HEV's
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N:C ratios
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All (?) Bcells have hi N:C, 90% of THelpers do, 50% of Tc do
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follicular dendritic cells present to __cells rather than __cells
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B, T - cause lack MHCII molecules
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APC's found primarily where? Most have what class molecule?
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APCs = macs, Bcells, interdigitating, follic. dendritic
-found in skin, lymph nodes, spleen, thymus -have MHCII except follics |
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Macrophages when found in skin called...
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Langerhan cell
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Phagocytes
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monocytes/macrophages (when leave blood mono=mac)
polymorphonuclear granulocytes |
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accessory cells
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APC's, platelets, endothelial cells
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Mac/mono cell markers
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Fc recep for IgG
complement receps MHCII receps cytokine receps |
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Neutrophil primary granules
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lysosomes containing acid hydrolases, myeloperoxidase, muramidase
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Eosinophils can kill parasitic worms by____
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degranulation
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Leslie hates_____
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immunology
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Basophils found where?
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circulating blood
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MHC is set of genes on long strand of DNA on chr # ___
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6
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MHCI encodes...
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glycoproteins expressed nearly all nucleated cells which present antigens of altered self cells
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MHCII encodes...
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glycoproteins expressed on APC's
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