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99 Cards in this Set
- Front
- Back
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True or False: A. MHC co-dominancy means both parental copies of MHC will be expressed in one person, not necessarily on each of his/her cells
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False
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4. Which of the following is involved in MHC II pathway?
A. beta-2 microglobulin B. DM C. Proteosome D. TAP |
DM
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Which Ab is most prominent in mucosal immunity?
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IgA
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3 things that contribute to BCR diversity
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Affinity maturation
Combinatorial factor Junctional Diversity |
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What process do developing T cells undergo that developing B cells do not?
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Positive selection
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True or False: Polymorphism of MHC means the population diversity of MHC in one particular MHC locus
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True
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1. Which of the following cytokines promote Th2 differentiation?
A. IL-1 B. IL-2 C. IL-4 D. IL-6 |
IL-4
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Where does isotype switching take place?
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Paracortex
Germinal Center |
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Where does affinity maturation take place?
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Germinal Center
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Where does allelic exclusion take place?
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Bone marrow
Thymus |
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2 functions of IgM
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BCR
Complement activation |
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1 function of IgD
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BCR
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3 functions of IgA
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neonatal immunity
mucosal immunity complement activation |
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1 function of IgE
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ADCC
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Classes of Ig that are involved in ADCC
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IgG
IgE |
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Mancini assay
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??
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Ouchterlony assay
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??
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Assay to detect cytokine production
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Eli-spot
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Assay to detect IgA deficiency
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immunoelectrophoresis
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BCG
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??
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5. Which Ig found in the serum of a week old newborn would indicate a fetal infection?
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IgM
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4 diseases strongly associated with MHC I allele
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Ankylosing spondilitis
acute anterior uveitis Reiter syndrome Reactive arthritis |
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Ankylosing spondilitis
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??
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Autoimmune disease more common in men than in women
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Reactive arthritis
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Celiac disease is which Type of hypersensitivity?
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Type IV
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Cytopenia is associated with which type of hypersensitivity?
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Type II
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Most common type of congenital immune deficiency?
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B cell
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Which is the most common deficiency that leads to typical recurrent infection in sinus and lung specifically?
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IgA deficiency
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Which SCID is not recommended to be treated with bone marrow transplant?
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Omenn
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Omenn
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??
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What is the significant sign indicating immune deficiency?
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Patient experiences recurrent infection.
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T cell deficiency involving Fas or FasL deficiency leads to...
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ALPS
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ALPS
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???
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Hyper IgE results from ____
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Lack of Th1 or IFN-g production
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RAG-deficiency leads to which type of SCID?
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T-B-
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Omenn is which type of SCID?
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T+B-
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X-linked SCID leads to which deficiency?
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T-B+
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BLS
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??
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Symptoms of GVHD
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rash and diarrhea
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normal proteins vs. viral proteins vs. oncogene products
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??
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5 diseases with strong MHC II association
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Celiac disease
rheumatoid arthritis pemphigus vulgaris narcolepsy Type I DM |
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Bacterial infections associated with Reiter's syndrome
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Chlamydia
Shigella |
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Bacterial infection associated with Reactive arthritis
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Salmonella
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Viruses associated with MS
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Hep B
EBV HSV-6 Influenza A |
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6 symptoms of SLE
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butterfly malar rash
joint pain CNS abnormalities heart disease photosensitivity kidney disease |
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UV light is associated with which autoimmune disease?
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SLE
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5 Type IV HSR diseases
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allergic encephalitis
Celiac disease Type I DM MS RA |
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3 autoimmune diseases in which the mediator is unknown
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ankylosing spondylitis
reactive arthritis Reiter's syndrome |
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Goodpasture's syndrome
- type of HSR - target/antigen -consequence |
Type II
base membrane collagen in kidney, lung nephritis, lung hemorrhage |
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Myasthenia Gravis
- type of HSR -target/antigen -consequence |
Type II
AChR = target muscle paralysis |
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Graves' Disease
Type of HSR Target/Antigen Consequences |
Type II
TSH receptor hyperthyroidism |
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Rheumatoid Factor
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autoantibody against IgG
Found in 70% of RA cases |
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ANA
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autoantibody against dsDNA
seen in SLE |
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early complement component deficiency found in which autoimmune disease?
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SLE
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major effector in Type I DM
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CTL
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Plasmapheresis and High doses of IgG are treatments specific for which kinds of autoimmune disease?
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Ab-mediated
Immune-complex mediated |
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BCG vaccine =
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live or attenuated intracellular bacteria
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Complement deficiency makes the patient more susceptible to...
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bacterial infection
autoimmunity |
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Deficiency in C3 -->
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susceptible to pyogenic infection
fatal in early life |
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Deficiency in C2, C4 -->
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high risk developing immune-complex diseases
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Deficiency in C9 -->
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susceptibility to Neisseria infection
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host factors that prevent reandom cell lysis
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C1 INH
DAF MCP CR1 |
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C1 INH
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C1 esterase inhibitor
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HANE
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deficiency in C1 INH
localized edema in airway, intestine, skin |
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PNH
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caused by somatic DNA mutations in proteins essential for GPI production
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GPI deficiency
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spontaneous lysis of RBC, platelets, granulocytes
anema, TTP, chronic infection |
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LAD
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leukocyte adhesion deficiency
autosomal recessive defect in integrins affects WBC migration |
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symptoms of LAD
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high WBC counts
no pus formation, no effective wound heaing no classical signs during infection |
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CGD
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chronic granulomatous disease
X-linked or autosomal recessive defect in respiratory burst, affects phagocytic killing |
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symptoms of CGD
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susceptible to low virulence bacteria
widespread granulomas, may obstruct stomach, esophagous or bladder |
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Chediak-Higashi Syndrome
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autosomal recessive
defect in vesicle fusion affects degranuation & phagocytes |
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symptoms of Chediak Higashi
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recurrent infection by pyogenic organisms
associated with neutropenia and massive infiltration of Mf and lymphocytes to liver, spleen, LN |
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4 types T cell deficiency
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DiGeorge Syndrome
ALPS Hyper-IgE syndrome Hyper-IgM syndrome |
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ALPS
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Autoimmune LymphoProliferative Syndrome
defective in Fas, FasL or Caspase 10 increasing number CD4-CD8- T cells |
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symptoms of ALPS
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susceptible to chronic viral infection
prone to develop B cell lymphoma |
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Hyper-IgE syndrome
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Th1 cells fail to produce IFN-gamma
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Hyper-IgM syndrome
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mutations in CD40, CD40L
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XLA
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X-lined infantile Agammaglobulinemia
mutation of btk blocking maturation from preB virtual absence of B cells |
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symptoms of XLA
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recurrent pyogenic bacteria infections
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IgA deficiency symptoms
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recurrent sinus and lung infections
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T-B- types of SCID
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ADA
PNP RAG deficiency |
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T+B+ SCID
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BLS
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Cause of T-B+: X-linked SCID
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mutation of common gamma-chain
normal B cell number but no function |
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Cause of T-B+: autosomal SCID
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mutation of JAK3 Tyr-Kinase (mediates signaling downstream from common gamma receptor)
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ADA deficiency causes
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accumulation of toxins, impairing lymphocyte development
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PNP deficiency causes...
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toxin accumulation leading to damages in neuological and lymphoid tissues
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BM transplant not recommended for which SCID?
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Omenn
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Etiology of Omenn syndrome
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partial SCID with reduced RAG activity affecting only B cell development
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3 SCID like multisystem disorders
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ZAP-70 mutation
Wiskott-Adrich Syndrome Ataxia Telangiectasia |
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Mechanisms of Wiskott-Aldrich
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mutations in WASP
reduced T cell count abnormal B & T cell function |
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Mechanism of ataxia telangiectasia
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mutation in DNA repair protein
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Tx for ADA deficiency
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BM transplant
gene replacement enzyme replacement |
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oncogene product
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Bcr/Abl
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USES OF IMMUNOASSAYS!
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STUDY!
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Ouchterlony tests...
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if antigens are related
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Agglutination is targeted at a _____ antigen
Precipitation is targeted at a ____ antigen |
Agglutination - particle antigen
Precipitation - soluble antigen |
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FACS determines
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cell types and numbers
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IF detects
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antigens embedded in tissues or cells
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Mancini determines
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protein concentration
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