Immunology Exam 2: Cytokines

Front 1

Function of IL-1

Back 1

Produces fever.
Stimulates acute-phase protein synthesis.
Promotes proliferation of TH2 cells.

Front 2

Function of IL-2

Back 2

T-Cell growth factor

Front 3

Function of IL-3

Back 3

Growth factor for hematopoietic cells

Front 4

Function of IL-4

Back 4

Growth factor for B cells and TH2 CD4+ T-Cells.
Promotes IgE and IgG synthesis.
Inhibits TH1 CD4+ T-Cells.

Front 5

Function of IL-5

Back 5

Stimulates B-Cell growth and Ig secretion.
Growth and differentiation factor Eosinophils.

Front 6

Function of IL-6

Back 6

Induces acute-phase protein synthesis.
T-Cell activation.
IL-2 Production.
Stimulates B-Cell Ig production and hematopoietic progenitor cell growth.

Front 7

Function of IL-7

Back 7

Growth factor for pre-T and pre-B cells.

Front 8

Function of IL-9

Back 8

Mast cell activation.

Front 9

Function of IL-10

Back 9

Inhibits production of TH1 cells.
Inhibits macrophage function.

Front 10

Function of IL-11

Back 10

Stimulates megakaryocyte (platelet precursor) growth.

Front 11

Function of IL-12

Back 11

Activates NK cells.
Promotes generation of TH1 CD4+ T-Cells.

Front 12

Function of IL-13

Back 12

Shares characteristics with IL-4 (Ig switch to IgE synthesis) but does not affect T-Cells.
Growth factor for human B-Cells.

Front 13

Function of IL-14

Back 13

Involved in development of memory B-Cells.

Front 14

Function of IL-15

Back 14

T-Cell growth factor.
Similar to IL-2.

Front 15

Function of IL-16

Back 15

Chemotactic for T-Cells.
Proinflammatory.

Front 16

Function of IL-17

Back 16

Proinflammatory cytokine.
Promotes Neutrophil migration and differentiation.
Plays decisive role in autoimmunity and immune-mediated tissue damage.

Front 17

Function of IL-18

Back 17

Induces IFN-γ production.
Enhances NK cell lytic activity.

Front 18

Function of IL-23

Back 18

Acts on memory T-Cells to stimulate IL-17 secretion.

Front 19

Function of IFN-γ

Back 19

Activates NK cells and macrophages.
Inhibits TH2 CD4+ T-Cells.
Induces expression of MHC II on many cell types.

Front 20

Function of TGF-β

Back 20

Enhances production of IgA.
Inhibits activation of monocyte and T-Cell subsets.
Active in Fibroblast growth and wound healing.

Front 21

Function of TNF-α

Back 21

Involved in inflammatory reponses.
Activates endothelial cells andother cells of immune and nonimmune systems.
Induces fever and septic shock.

Front 22

Function of TNF-β

Back 22

AKA Lymphotoxin.
Involved in inflammatory responses.
Plays a role in killing target cells by cytotoxic CD8+ T-Cells.

Front 23

Function of GM-CSF

Back 23

Promotes growth of granulocytes and macrophages.
Growth of Dendritic cells in-vitro.

Front 24

Function of M-CSF

Back 24

Promotes macrophage growth.

Front 25

Function of G-CSF

Back 25

Promotes granulocyte growth.

Front 26

Which cytokines induce fever?

Back 26

TNF-α ("induces" fever)
IL-1 ("produces" fever)

Front 27

Which cytokines are involved in Proinflammatory responses VS. Inflammatory responses?

Back 27

Proinflammatory:
IL-16
IL-17

Inflammatory:
TNF-α
TNF-β

Front 28

Which cytokines are T-Cell growth factors VS. T-Cell activators?

Back 28

T-Cell growth factors:
IL-2
IL-4 (for TH2 CD4+ T-Cells)
IL-15

T-Cell activators:
IL-6
IL-12 (promotes generation of TH1 CD4+ T-Cells)

Front 29

Which cytokines stimulate acute-phase protein synthesis?

Back 29

IL-1
IL-6

Front 30

Which cytokine is a growth factor for TH2 CD4+ T-Cells but also an inhibitor for TH1 CD4+ T-Cells?

Back 30

IL-4

Front 31

Which cytokine promotes proliferation of TH2 cells?

Back 31

IL-1

Front 32

Which cytokine is a growth factor for Hematopoietic cells?

Back 32

IL-3
IL-6 (stimulates hematopoietic progenitor cell growth)

Front 33

Which cytokines are growth factors for B-Cells?

Back 33

IL-4
IL-5 (stimulates B-Cell growth and Ig secretion)
IL-6 ("stimulates B-Cell production of Ig's")
IL-13

Front 34

Which cytokines are involved in development of Memory B-Cells and Memory T-Cells?

Back 34

Memory B-Cells:
IL-14

Memory T-Cells:
IL-23 (stimulates secretion of IL-17 by acting on Memory T-Cells)

Front 35

Which cytokine is a growth and differentiation factor for Eosinophils?

Back 35

IL-5

Front 36

Which cytokine is involved in Mast cell activation?

Back 36

IL-9

Front 37

Which cytokine is responsible for inhibition of the production of TH1 cells and inhibition of macrophage function?

Back 37

IL-10

Front 38

Which cytokine is a growth factor for pre-T and pre-B Cells?

Back 38

IL-7

Front 39

Which cytokine stimulates megakaryocyte (platelet precursor) growth?

Back 39

IL-11

Front 40

Which cytokines activate NK cells?

Back 40

IL-12
IL-18 (enhances NK cell lytic activity)
IFN-γ

Front 41

Which cytokine is similar to IL-2?
(same function) What are their functions?

Back 41

IL-15

Front 42

Function of IL-2 and IL-15:

Back 42

T-Cell growth factor

Front 43

Which cytokine is similar to IL-4?How so, you smart ass?
What are their differences?

Back 43

IL-4 and IL-13 are similar.

Similar: Growth factor for human B-Cells and promotes IgE and IgG synthesis.

Differences: IL-13 does not affect T-Cells.
(IL-4 is a growth factor for TH2 CD4+ T-Cells and inhibits TH1 CD4+ T-Cells.)

Front 44

Which cytokines are responsible for B-Cell growth and Ig production/synthesis?

Back 44

IL-5
IL-6

Front 45

Which cytokine is involved in the production of IL-2?

Back 45

IL-6

Front 46

List the cytokines that promotes proliferation and the inhibition of TH1 CD4+ T-Cells?

Back 46

Proliferation of TH1 CD4+ T-Cells:
IL-12

Inhibition of TH1 CD4+ T-Cells:
IL-4

Front 47

List the cytokines that promotes proliferation and the inhibition of TH2 CD4+ T-Cells?

Back 47

Proliferation of TH2 CD4+ T-Cells:
IL-4

Inhibition of TH2 CD4+ T-Cells:
IFN-γ

Front 48

Which cytokine induces IFN-γ production?

Back 48

IL-18

Front 49

Which cytokine promotes Neutrophil migration and differentiation?

Back 49

IL-17 family (IL-17A - IL-17F)

Front 50

Which cytokine induces expression of MHC II on many cell types?

Back 50

IFN-γ

Front 51

Which cytokine induces fever and septic shock?

Back 51

TNF-α

Front 52

Which cytokine plays a decisive role in autoimmunity and immune-mediated tissue damage?

Back 52

IL-17 family (A-F)

Front 53

Which cytokine is Chemotactic for T-Cells?

Back 53

IL-16

Front 54

Which cytokine activates both NK cells and Macrophages?

Back 54

IFN-γ

Front 55

Which cytokine promotes IgE and IgG synthesis?

Back 55

IL-4

Front 56

Which cytokine enhances production of IgA?

Back 56

TGF-β

Front 57

Which cytokine inhibits activation of monocytes?

Back 57

TGF-β

Front 58

Which cytokine inhibits activation of monocyte and T-Cell subsets?

Back 58

TGF-β

Front 59

Which cytokine is active in fibroblast growth?

Back 59

TGF-β

Front 60

Which cytokine is active in wound healing?

Back 60

TGF-β

Front 61

Which cytokine activates endothelial cells and other cells of immune and nonimmune systems?

Back 61

TNF-α

Front 62

Which cytokine plays a role in killing target cells by cytotoxic CD8+ T-Cells?

Back 62

TNF-β (Lymphotoxin)

Front 63

Which cytokine promotes growth of Granulocytes and Macrophages?

Back 63

GM-CSF

Front 64

Which cytokine is involved in the growth of Dendritic cells in-vitro?

Back 64

GM-CSF

Front 65

Which cytokines are involved in promoting Macrophage growth?

Back 65

IFN-γ ("activation of Macrophages)
GM-CSF ("promotes growth")
M-CSF ("promotes growth")

Front 66

Which cytokine is involved in promoting Granulocyte growth?

Back 66

G-CSF