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66 Cards in this Set

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Function of IL-1
Produces fever.
Stimulates acute-phase protein synthesis.
Promotes proliferation of TH2 cells.
Function of IL-2
T-Cell growth factor
Function of IL-3
Growth factor for hematopoietic cells
Function of IL-4
Growth factor for B cells and TH2 CD4+ T-Cells.
Promotes IgE and IgG synthesis.
Inhibits TH1 CD4+ T-Cells.
Function of IL-5
Stimulates B-Cell growth and Ig secretion.
Growth and differentiation factor Eosinophils.
Function of IL-6
Induces acute-phase protein synthesis.
T-Cell activation.
IL-2 Production.
Stimulates B-Cell Ig production and hematopoietic progenitor cell growth.
Function of IL-7
Growth factor for pre-T and pre-B cells.
Function of IL-9
Mast cell activation.
Function of IL-10
Inhibits production of TH1 cells.
Inhibits macrophage function.
Function of IL-11
Stimulates megakaryocyte (platelet precursor) growth.
Function of IL-12
Activates NK cells.
Promotes generation of TH1 CD4+ T-Cells.
Function of IL-13
Shares characteristics with IL-4 (Ig switch to IgE synthesis) but does not affect T-Cells.
Growth factor for human B-Cells.
Function of IL-14
Involved in development of memory B-Cells.
Function of IL-15
T-Cell growth factor.
Similar to IL-2.
Function of IL-16
Chemotactic for T-Cells.
Proinflammatory.
Function of IL-17
Proinflammatory cytokine.
Promotes Neutrophil migration and differentiation.
Plays decisive role in autoimmunity and immune-mediated tissue damage.
Function of IL-18
Induces IFN-γ production.
Enhances NK cell lytic activity.
Function of IL-23
Acts on memory T-Cells to stimulate IL-17 secretion.
Function of IFN-γ
Activates NK cells and macrophages.
Inhibits TH2 CD4+ T-Cells.
Induces expression of MHC II on many cell types.
Function of TGF-β
Enhances production of IgA.
Inhibits activation of monocyte and T-Cell subsets.
Active in Fibroblast growth and wound healing.
Function of TNF-α
Involved in inflammatory reponses.
Activates endothelial cells andother cells of immune and nonimmune systems.
Induces fever and septic shock.
Function of TNF-β
AKA Lymphotoxin.
Involved in inflammatory responses.
Plays a role in killing target cells by cytotoxic CD8+ T-Cells.
Function of GM-CSF
Promotes growth of granulocytes and macrophages.
Growth of Dendritic cells in-vitro.
Function of M-CSF
Promotes macrophage growth.
Function of G-CSF
Promotes granulocyte growth.
Which cytokines induce fever?
TNF-α ("induces" fever)
IL-1 ("produces" fever)
Which cytokines are involved in Proinflammatory responses VS. Inflammatory responses?
Proinflammatory:
IL-16
IL-17

Inflammatory:
TNF-α
TNF-β
Which cytokines are T-Cell growth factors VS. T-Cell activators?
T-Cell growth factors:
IL-2
IL-4 (for TH2 CD4+ T-Cells)
IL-15

T-Cell activators:
IL-6
IL-12 (promotes generation of TH1 CD4+ T-Cells)
Which cytokines stimulate acute-phase protein synthesis?
IL-1
IL-6
Which cytokine is a growth factor for TH2 CD4+ T-Cells but also an inhibitor for TH1 CD4+ T-Cells?
IL-4
Which cytokine promotes proliferation of TH2 cells?
IL-1
Which cytokine is a growth factor for Hematopoietic cells?
IL-3
IL-6 (stimulates hematopoietic progenitor cell growth)
Which cytokines are growth factors for B-Cells?
IL-4
IL-5 (stimulates B-Cell growth and Ig secretion)
IL-6 ("stimulates B-Cell production of Ig's")
IL-13
Which cytokines are involved in development of Memory B-Cells and Memory T-Cells?
Memory B-Cells:
IL-14

Memory T-Cells:
IL-23 (stimulates secretion of IL-17 by acting on Memory T-Cells)
Which cytokine is a growth and differentiation factor for Eosinophils?
IL-5
Which cytokine is involved in Mast cell activation?
IL-9
Which cytokine is responsible for inhibition of the production of TH1 cells and inhibition of macrophage function?
IL-10
Which cytokine is a growth factor for pre-T and pre-B Cells?
IL-7
Which cytokine stimulates megakaryocyte (platelet precursor) growth?
IL-11
Which cytokines activate NK cells?
IL-12
IL-18 (enhances NK cell lytic activity)
IFN-γ
Which cytokine is similar to IL-2?
(same function) What are their functions?
IL-15
Function of IL-2 and IL-15:
T-Cell growth factor
Which cytokine is similar to IL-4?How so, you smart ass?
What are their differences?
IL-4 and IL-13 are similar.

Similar: Growth factor for human B-Cells and promotes IgE and IgG synthesis.

Differences: IL-13 does not affect T-Cells.
(IL-4 is a growth factor for TH2 CD4+ T-Cells and inhibits TH1 CD4+ T-Cells.)
Which cytokines are responsible for B-Cell growth and Ig production/synthesis?
IL-5
IL-6
Which cytokine is involved in the production of IL-2?
IL-6
List the cytokines that promotes proliferation and the inhibition of TH1 CD4+ T-Cells?
Proliferation of TH1 CD4+ T-Cells:
IL-12

Inhibition of TH1 CD4+ T-Cells:
IL-4
List the cytokines that promotes proliferation and the inhibition of TH2 CD4+ T-Cells?
Proliferation of TH2 CD4+ T-Cells:
IL-4

Inhibition of TH2 CD4+ T-Cells:
IFN-γ
Which cytokine induces IFN-γ production?
IL-18
Which cytokine promotes Neutrophil migration and differentiation?
IL-17 family (IL-17A - IL-17F)
Which cytokine induces expression of MHC II on many cell types?
IFN-γ
Which cytokine induces fever and septic shock?
TNF-α
Which cytokine plays a decisive role in autoimmunity and immune-mediated tissue damage?
IL-17 family (A-F)
Which cytokine is Chemotactic for T-Cells?
IL-16
Which cytokine activates both NK cells and Macrophages?
IFN-γ
Which cytokine promotes IgE and IgG synthesis?
IL-4
Which cytokine enhances production of IgA?
TGF-β
Which cytokine inhibits activation of monocytes?
TGF-β
Which cytokine inhibits activation of monocyte and T-Cell subsets?
TGF-β
Which cytokine is active in fibroblast growth?
TGF-β
Which cytokine is active in wound healing?
TGF-β
Which cytokine activates endothelial cells and other cells of immune and nonimmune systems?
TNF-α
Which cytokine plays a role in killing target cells by cytotoxic CD8+ T-Cells?
TNF-β (Lymphotoxin)
Which cytokine promotes growth of Granulocytes and Macrophages?
GM-CSF
Which cytokine is involved in the growth of Dendritic cells in-vitro?
GM-CSF
Which cytokines are involved in promoting Macrophage growth?
IFN-γ ("activation of Macrophages)
GM-CSF ("promotes growth")
M-CSF ("promotes growth")
Which cytokine is involved in promoting Granulocyte growth?
G-CSF