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43 Cards in this Set
- Front
- Back
Innate or Acquired: Antigen Nonspecific
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Innate
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Innate or Acquired: Rapid Response (minutes/hours)
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Innate
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Innate or Acquired: Natural Barriers (eg. skin, mucous membranes)
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Innate
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Innate or Acquired: No memory
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Innate
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Innate or Acquired: Phagocytes and Natural Killer Cells
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Innate
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Innate or Acquired: Soluble Mediators (eg. complement)
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Innate
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Innate or Acquired: Pattern Recognition Molecules
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Innate
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Innate or Acquired: Antigen Specific
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Acquired
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Innate or Acquired: Slow response (days)
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Acquired
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Innate or Acquired: Has memory
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Acquired
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Innate or Acquired:
Lymphocytes are immune component. |
Acquired
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Innate or Acquired:
Antigen Recognition Molecules (B and T cell receptors) |
Acquired
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Innate or Acquired:
Secreted Molecules (eg. Antibodies) |
Acquired
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Innate or Acquired:
A short response influenced by Genetics |
Innate
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Innate or Acquired:
pH and secreted fatty acids |
Innate
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Innate or Acquired:
Interferon |
Innate
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Innate or Acquired:
Pattern recognition molecules |
Innate
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Innate or Acquired:
Toll-like receptors |
Innate
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Innate or Acquired:
Serum proteins = B-Lysin, Lysozome, Polyamines, and Kinins. |
Innate
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Innate or Acquired:
Complement |
Innate
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Innate or Acquired:
Late in evolution of vertebrates |
Acquired
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Innate or Acquired:
Antigenic Stimulation |
Acquired
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Innate or Acquired:
Proliferation of B cells and T cells (clonal) |
Acquired
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Innate or Acquired:
Typically takes weeks but produces "memory" |
Acquired
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Innate or Acquired:
Vaccinations |
Acquired
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Define:
Active Immunization |
Immunization of an individual by administration of an antigen.
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What type of immunization is: Immunization of an individual by administration of an antigen.
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Active Immunization
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Define:
Passive Immunization |
Immunization though transfer of specific antibody from an immunized individual to a non-immunized individual.
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What type of immunization is:
Immunization though transfer of specific antibody from an immunized individual to a non-immunized individual. |
Passive Immunization
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Define:
Adoptive Immunization |
Transfer of immunity by the transfer of immune cells.
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What type of immunity:
Transfer of immunity by the transfer of immune cells. |
Adoptive Immunization
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Which immune response is characterized by:
Specificity being unique rather than random? |
Acquired
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Which immune response is characterized by:
It's adaptiveness is able to respond to "unseen" molecules? |
Acquired
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Which immune response is characterized by:
Discrimination between self and non-self is conferred by Lymphocytes that bear antigen-specific receptors on their surfaces? |
Acquired
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Which immune response is characterized by:
Memory is able to recall previous interaction with foreign molecule (anamnestic response)? |
Acquired
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What is the Clonal Selection Theory of B cells
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A widely accepted model for how the immune system responds to infection and how certain types of B and T lymphocytes are selected for destruction of specific antigens invading the body.
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Physical and Chemical barriers of Innate Immunity
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pH of sweat and sebaceous secretions.
Keratinized Skin (dead, grows outward and sloughs away) Fatty acids and Hydrolytic enzymes. Interferons (released to create anti-viral state). Complement (enzymatic cascade that targets membranes). Mucous and ciliary elevator. |
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Pathway of Intracellular and Extracellular killing of Microorganisms
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1. Tissue injury: release of chemical signals such as Histamine.
2. Dilation and increased leakiness of local blood vessels: Migration of phagocytes to the area. 3. Phagocytes (macrophages and neutrophils) consume bacteria and cell debris - tissue heals. |
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Basophils, Mast Cells, Eosinophils, and Neutrofils make up the _________ Leukocytes
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(innate immunity)
PMN Leukocytes (polymorphonuclear) |
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Kupffer cells, Avleolar, Splenic, Peritoneal, and Microglial cells make up the __________
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Macrophages
Kupffer cells: Liver Aveolar Macrophages: Lungs Splenic Macrophages: why is the spleen a strategic location? Peritoneal Macrophages Microglial cells: CNS |
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What cells are involved in the Innate Immune system?
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PMN cells
Macrophages Dendritic Cells |
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Effects of Kinins in Inflammation
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Cause muscle contraction.
Block nervous impulses leading to distal muscle relaxation. Nerve stimulators associated with pain and itching. Vasoactive Bradykinin causes endothelial cells to contract and express endothelial cell adhesion molecules (ECAMs). |
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Characteristics of Systemic Inflammatory Responses
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Fever.
Increased Blood cell production. Production of c-reactive protein (acute phase proteins) Cytokines (released by activated macrophages). -> Interleukins -> Tumor necrosis factor Result is amplification of Immune response. Anti-inflammatory Drugs (aspirin, ibuprofen, cortisone) target metabolic pathways that produce the mediators of inflammation. |