Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
27 Cards in this Set
- Front
- Back
T-dependent antigens
|
Proteins
|
|
Polysaccharides, lipids, small chemicals, nucleic acids
|
T-independent antigens
|
|
B cell population that resides in follicles of lymph nodes
|
Follicular B cells
|
|
B cell population that resides in marginal zones of spleen
|
Marginal zone B (MZB) cells
|
|
B cell population that resides in mucosa and peritoneum
|
B-1 B cells
|
|
B cell populations that produce primarily IgM
|
MZB cells and B-1 B cells
|
|
Major antibody produced in primary response
|
IgM
|
|
Major antibody produced in secondary response
|
IgG, IgA, IgE
|
|
Components of B cell co-receptor complex
|
CR2 (CD21); CD19; CD81
|
|
Components of B cell antigen receptor complex
|
BCR; Iga, Igb
|
|
Ligand for CR2
|
C3d (and iC3b)
|
|
Anatomical site of activation of naive B cells
|
B cell zones of lymphoid tissues
|
|
Mechanism of helper T cell-induced activation of B cells
|
CD40L and cytokines
|
|
Effector mechanism of B cells in humoral immunity
|
Secretion of antibodies
|
|
Inducers of heavy chain isotype switching
|
CD40L and cytokines
|
|
Basis of X-linked hyper-IgM syndrome
|
Defective CD40L
|
|
Enzyme that induces switch recombination
|
Activation-induced deaminase (AID)
|
|
Major cytokine that induces switching to IgG
|
IFNg
|
|
Major cytokine that induces switching to IgE
|
IL-4
|
|
Major cytokine that induces switching to IgA
|
TGFb
|
|
Process that increases affinity of antibody for antigen
|
Affinity maturation
|
|
Anatomical site where affinity maturation occurs
|
Germinal centers of lymphoid follicles
|
|
Enzyme that results in numerous point mutations in Ig genes
|
AID
|
|
Mechanism of affinity maturation
|
Somatic hypermutation
|
|
This type of antigen induces primarily an IgM response
|
T-independent antigens
|
|
This type of antigen results in isotype switching
|
T-dependent antigens
|
|
Receptor that mediates antibody feedback
|
FcgRII receptor
|