Immunology: Chapter 3

Front 1

Processed peptides bound to MHC molecules

Back 1

T cell antigens

Front 2

Recognition by T cells of peptides bound to one’s own MHC molecules

Back 2

MHC restriction

Front 3

Cells that capture and present peptides to T cells

Back 3

Antigen-presenting cells (APC)

Front 4

Dendritic cells, macrophages, B cells

Back 4

Professional APC’s

Front 5

Another name for immature dendritic cell in the skin

Back 5

Langerhans cell

Front 6

Transports antigen from epithelia to draining lymph node

Back 6

Dendritic cells

Front 7

Destination of antigens captured in epithelia and sub-epithelial tissues

Back 7

Lymph nodes, MALT, GALT, BALT

Front 8

Destination of blood-borne antigens

Back 8

Spleen

Front 9

Microbial-induced activators of dendritic cells

Back 9

TNF, IL-1, TLR signaling

Front 10

Destination of dendritic cells in lymph nodes

Back 10

T cell zones

Front 11

Chemical signal that attracts activated dendritic cells to draining lymph node

Back 11

Chemokines that bind to CCR7 on dendritic cell

Front 12

Afferent lymphatic vessel—lymph node---efferent lymphatic vessel

Back 12

Flow of lymph through a draining lymph node

Front 13

Human Major Histocompatibility Complex (MHC) proteins

Back 13

Human Leukocyte Antigens (HLA)

Front 14

Genes that encode the Class I MHC molecules

Back 14

HLA-A, B, C

Front 15

Cells that express Class I MHC molecules

Back 15

All nucleated cells

Front 16

Genes that encode the Class II MHC molecules

Back 16

HLA-DP, DQ, and DR

Front 17

Cells that express Class II MHC molecules

Back 17

Professional APC’s

Front 18

Set of MHC alleles present on each chromosome

Back 18

MHC haplotype

Front 19

MHC molecules that are recognized by CD8+ T cells

Back 19

Class I

Front 20

MHC molecules that are recognized by CD4+ T cells

Back 20

Class II

Front 21

Domains of peptide-binding groove of MHC Class I molecules

Back 21

α1:α 2

Front 22

CD8 binding site of MHC Class I molecule

Back 22

α 3

Front 23

Domains of peptide-binding groove of MHC Class II molecules

Back 23

α1:β1

Front 24

CD4 binding site of MHC Class II molecule

Back 24

β2

Front 25

Source of antigens for MHC Class I molecules

Back 25

Endogenous cytosolic proteins

Front 26

Source of antigens for MHC Class II molecules

Back 26

Endosomes/Lysosomes

Front 27

Site of peptide loading for MHC Class I molecule

Back 27

Endoplasmic reticulum

Front 28

Site of peptide loading for MHC Class II molecule

Back 28

Vesicle

Front 29

Enzymes that generate peptides for MHC Class I molecules

Back 29

Proteasome

Front 30

Enzymes that generate peptides for MHC Class II molecules

Back 30

Proteases in vesicles

Front 31

T cell population that responds to peptide: MHC Class II molecules

Back 31

CD4+ T cells

Front 32

T cell population that responds to peptide: MHC Class I molecules

Back 32

CD8+ T cells