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24 Cards in this Set

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Primary myedema thyrotoxicosis

Thyroid

Hashimotos thyroiditis

Thyroid

Pernicious anemia

Stomach

Dermatomyosis

Muscle

Scleroderma

Skin

Juvenile diabetes

Pancreas

Addisons disease

Adrenal

SLE

Kidney

Rheumatoid arthritis

Joints

Autoimmune diseases


Are characterized by:

Persistent activation of immunologic effector mechanisms



That alter the function and integrity of



Individual cells and organs

Factors that influence the development of autoimmunity

Genetic factors



Age



Exogenous

Cardiovascular

Vasculitis


Carditis

Reproductive disorders


Caused by:

Autoantibodies

Pernicious anemia is:

Decreased synthesis of intrinsic factor

Forms of lupus:

Discoid (cutaneous) 10%


Drug induced


Systemic 70%


Mixed connective tissue disease

SLE


Humoral aspects:

The absence of ANA virtually excludes the dx of SLE


Unless pt is chemically immunocomprmised

SLE


DX:


Histological changes:

Nuclear debris reacts w/antinuclear antibodies to form


Hematoxylin bodies

What is the hallmark of dx-ing SLE


The presence of ANA

Types of ANA


Antinuclear antibodies

Abs to:


DNA


his tones


Non histone proteins


NucleOlar Ag


Scleroderma

Collagen vascular disorder


Associated w/occupations and drugs


3 X more in women


Thickening of fibrosis


Sjogrens syndrome

Exocrine gland disorder


Affects tear duct


Salivary


And other excretion glands


90% are women

Hashimotos

Developement of Circulating cytotoxic Abs


Goiter



Multiple sclerosis

Demyelinating disease of CNS

Pancreas insulin dependant diabetes mellitis

Endocrine gland disorder


Caused by destruction of B cells. Of pancreatic islets