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24 Cards in this Set
- Front
- Back
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Primary myedema thyrotoxicosis |
Thyroid |
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Hashimotos thyroiditis |
Thyroid |
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Pernicious anemia |
Stomach |
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Dermatomyosis |
Muscle |
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Scleroderma |
Skin |
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Juvenile diabetes |
Pancreas |
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Addisons disease |
Adrenal |
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SLE |
Kidney |
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Rheumatoid arthritis |
Joints |
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Autoimmune diseases Are characterized by: |
Persistent activation of immunologic effector mechanisms
That alter the function and integrity of
Individual cells and organs |
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Factors that influence the development of autoimmunity |
Genetic factors
Age
Exogenous |
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Cardiovascular |
Vasculitis Carditis |
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Reproductive disorders Caused by: |
Autoantibodies |
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Pernicious anemia is: |
Decreased synthesis of intrinsic factor |
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Forms of lupus: |
Discoid (cutaneous) 10% Drug induced Systemic 70% Mixed connective tissue disease |
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SLE Humoral aspects: |
The absence of ANA virtually excludes the dx of SLE Unless pt is chemically immunocomprmised |
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SLE DX: Histological changes: |
Nuclear debris reacts w/antinuclear antibodies to form Hematoxylin bodies |
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What is the hallmark of dx-ing SLE
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The presence of ANA |
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Types of ANA Antinuclear antibodies |
Abs to: DNA his tones Non histone proteins NucleOlar Ag
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Scleroderma |
Collagen vascular disorder Associated w/occupations and drugs 3 X more in women Thickening of fibrosis
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Sjogrens syndrome |
Exocrine gland disorder Affects tear duct Salivary And other excretion glands 90% are women |
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Hashimotos |
Developement of Circulating cytotoxic Abs Goiter
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Multiple sclerosis |
Demyelinating disease of CNS |
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Pancreas insulin dependant diabetes mellitis |
Endocrine gland disorder Caused by destruction of B cells. Of pancreatic islets |
