• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off

Card Range To Study



Play button


Play button




Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

47 Cards in this Set

  • Front
  • Back
adhesive molecules
surface molecules that bind counter molecules on other cells causing close contact between the cells
afferent lymphatics
lymphatic vessels that enter the lymph nodes
alpha-beta TCR
refers to the T cell antigen heterodimeric receptor on more than 90% of T cells
alternative splicing
the process by which mRNA is spliced to create either a mu or a delta heavy chain constant region
the process by which a stimulus causes cells to become non responsive
the process by which cells under go self-induced suicide
refers to immunological responses against self antigens
the B cell receptor - refers to the antigen specific receptor on B cells
a molecule that is present on all B cells - therefore a panmarker
a molecule that is present on all T cells - therefore a panmarker
expressed in association with CD79b - the complex is expressed on the cell surface with BCR
expressed in association with CD79a - the complex is expressed on the cell surface with BCR
combinatorial diversity
a term that refers to the multitude of gene segments that comprise variable regions of BCR and TCR
death by neglect
refers to the phenomenon by which developing thymocytes die because they do no receive appropriate signals
diversity (D)
a gene segment that encodes a segment of the heavy chain Ig or the beta chain of the TCR but not light chain or TCR-alpha
down regulation
the process by which expression of cell surface molecules is decreased
efferent lymphatics
lymphatic vesels that leave tissues
gamma-delta TCR
refers to the T cell antigen heterodimeric receptor on about 10% of the T cells
germline DNA
refers to genomic DNA, DNA that has not been altered by recombinatorial events
a prominent filamentous layer on the surface of specialized endothelial cells
high endothelial venules
special post-capillary venules that serve as sites for lymphocytes to exit blood and enter lymph node parenchyma
adhesion molecules that induce firm contact between cells that have appropriate counter molecules
joining (J)
segment of DNA that encodes for a segment of the light and heavy chain variable regions (as well as TCR alpha-beta)
junctional diversity
the heterogeneity that results from either the removal or addition of bases at the junction of DNA segments V, D, J
one of the two light chain constant regions - the other is lambda
L selectin
a molecule whose interaction with counter molecules causes lymphocytes to roll on the endothelium
one of the two light chain constant regions - the other is kappa
lineage commitment
the process during T cell development in which CD8+, CD4+ thymocytes become CD8+ or CD4+ only
matrix metalloproteinases
enzymes that cause the degradation of endothelial cell wall to allow cells to pass from the blood vessels to tissues
membrane immunoglobulin, same as BCR
negative selection
destruction of developing thymocytes as a result of strong signals when thymocytes interact with thymic epithelium
refers to a cell suface molecule present on a particular cell type and not usually present on other cells
positive selection
the proliferation of developing thymocytes when they receive the appropriate signals
the precursor complex expresed on developing B cells prior to the expresion of the BCR complex
the chain that associates with the beta chain TCR to form a precursor complex on the developing T cells in the thymus
pseudo light chain
the chain that is associated with the heavy chain to form a precursor complex on developing B cells
recombination activating genes (RAG-1 and RAG-2)
genes that encode proteins required for somatic recombination of variable region of B cell or T cell angigen receptors
somatic recombination
the process by which DNA segments are rearranged to form a variable region for either the B cell or T cell receptor
the T cel receptor on the majority of T cells - it recognizes antigen-MHC complexes
the alpha chain of the T cell receptor
the beta chain of the T cell receptor
terminal deoxynucleotidyl transferase
an enzyme capable of catalyzing the template independent insertion of nucleotides between variable region segments
tolerance induction
the process by which the immune system remains non responsive to self antigen
the process by which DNA is converted to mRNA
the process by which mRNA is converted to protein
triggering threshold
the level of signal intensity beyond which cells are destroyed
variable (V)
the region present in each chain of the B cell and T cell antigen recognizing receptors