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30 Cards in this Set
- Front
- Back
TLR 4
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LPS recognition
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TLR2
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Peptidoglycan recognition
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TLR3
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Endosomal; DS viral RNA recognition
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TLR7
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Endosomal; SS viral RNA recognition
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TLR8
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Endosomal; SS viral RNA recognition
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Neutrophils
granules surface |
Extravasate to infection site; sign of infection
Surface: Secretes: IL-12 Specific granules: collegenase, elastase (for rebuilding) lysozyme (these are specific for PMN) Azurophilic granules: digestive, cathelcidin and defensins (natural microbials) (non-specific for PMN) MQ secrete chemokines to direct entrance surface: integrin receptor, selector ligand |
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Dendritic Cell
Activated by secretes activates function surface |
Activated by: IL-2, IFN-g, CD40:40L
Secretes: IL-12 aids in activation of TH1 (not TH2) and CTLs, TNF Activates: T cells TH (MHC, costim, cytokines)not TH2 CTL (direct, indirect, cross-pres) Function: Only one that can stim Naive T! Controlled Cross-present Surface: CCR7 (to bring to nodes);costim CD80/86, CD40, antigen receptors (TLRs!), CD25(IL-2r), ICAM-1, MHC(constit) |
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MQ
activated by secretes surface function |
Activated by: IFN-g (from NK, TH1)
Secretions: Activation: IL-12 (dif TH1); TNF Suppression:IL-1and TGF-B (to alter endothelial for extravasation) Surface: costim CD80/86, CD40, antigen receptors (TLRs), IFN-gR Function: Classical-Activation:Change endothelial for T and neutrophil, Phag, stim dif of TH1 Alternative-Suppression:Secrete IL-1, TNF, TGF-B, granuloma formation |
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IL-12
secreted by activates function stimulated by |
Secreted by: TH1 (autocrine), MQ, DC
Activates: MQ NK & TH1 (activates and to promotes IFN-g secretion); CTL (enhance cytosolic activity) Function: MQ activation to increase phagocyt via T cell intermend T cell activation (via MHC II) CTL activation (via MHC I) and incr cytotoxicity Stimulated by: TLR CD40:CD40L IFN-g (from NK) |
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IL-2
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Secreted by: activated T cell
Activates: TH1(autocrine), NK (stim IFN-g secretion), B cells Clonal Expansion (proliferation) |
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Licensing
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APC w/ no PAMPs in sight
Activated by T cell via CD40:CD40L (CD40 on APC)... stim APC to express CD80/86... so that APC can stim other T cells |
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TNF
secreted by activates function |
Secreted by: monocytes
Activates: monocytes, endothelial cells Function: monocyte recruitment Extravasation: chemokine change epithelial adhesion mol microbicidial |
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TGF-B
Secreted by Responds function |
Secreted by: T regs, activated T, MQ
Responds: inhibits T, MQ and counteract inflammation (from self-reg and "alt MQ activ" via TH2) IgA isotype switching tissue repair |
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Il-15
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Secreted by: MQ
Activates: NK (for viral infection) |
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IL-10
secreted by inhibits function |
Secreted by: Tregs, activated T cells, MQ
Inhibits: MQ("alt MQ activation" by TH2) T cell prolif; T cell effector Function: suppressive in stemming T cell and MQ activation Epstein-Barr is homologous |
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TH2
activated by secretes activates surface function MQ activation txt factors |
Activated by: IL-2 (prolif) IL-4 (dif)
Secretes: IL-4 (autocrine & IgE switch), IL-5 (helminth) Activates: TH2 dif, B cell isotype, Surface: IL-4r, CD25, Function: suppression via "alt MQ activ" responds to eosinophil (allergies) and helminth infection, granuloma formation "barrier immunity" MQ "Alt MQ activ" to secrete suppressive IL10 and TGF-B txt: GATA-3 (master), STAT6 to STAT6, GATA-3 |
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TH1
activated by secretes activates surface function MQ activation txt factors |
Activated by: IL-2(prolif) IL-4 (dif)
Secretes: IFN-g (autocrine & MQ activation) Activates: TH1 dif, MQ activation!!, complements Surface: CD25, IL-12r, IFN-gR, E/P selectin, integrin(r), CXCR5 and CCR5 (extrav), CD40L, CD28 Function:MQ activ (phag for inflamm), complement fixing, opsonizaation MQ activ "Classical Path" Txt factor: Tbet (control), STAT1 DTH Rxn (memory), can form granuloma (MQ cytokines, not TH1) |
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IL-5
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activates eosinophils
(ie. in helminth infection) secreted by: TH2, activated mast JAK/STAT pathway |
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IL-4
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involved in TH2 diff
prompts IgE switching in B cells secreted by: TH2, activated mast JAK/STAT pathway |
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IFN-g
secreted by affects function |
Secreted by: TH1, CD8+, NK
Affects: T into TH1, MQ, B cells, APCs Function: MQ activation- phag TH1 dif IgG isotype switching MHC I + II expression To increase inflamm rxns inhibit TH2 path |
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CRP
C Reactive Protein |
Opsinization: C1q binding and IgG FcR
Classical Pathway |
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MBL
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Aid Phagocytosis: binds Ag and Mannose on microbe surface
Complement Activation Lectin Pathway |
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Phagocytes recognize
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PAMP Receptors
Opsins (Ab, complements, lectins) |
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Classical Pathway
components binding |
C1q, has FcR
Cs2r2 starts w/ C4, C2 Binds Ab to Ag |
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Lectin Pathway
components binding |
MLB
MASP1, MASP2 starts w/ C4, C2 binds mannose on microbe surface |
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Alternative Pathway
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No C1q or MLB
C3b bind first Factor B --> c3 convertase |
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C1 INH
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inhibits C1s2r2 binding
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C59
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stops formation of MAC
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IL-7
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stimulates HSC into lymphoid line
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Hassal's corpsucle
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death of TEC; only in thymus
role iin Treg development |