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44 Cards in this Set
- Front
- Back
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Helper T cell subset Th1 |
Modulate and coordinate an immune response that is cell mediated |
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Helper T cell subset Th2 |
Modulate and coordinate an immune response that is antibody mediated |
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Tritiated thymidine uptake assay measures... |
Proliferation of T cells |
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Mixed lymph reaction measures... |
Evaluates histocompatibility |
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Cr 51 release cytotoxicity assay measures... |
Killing by CD8+ cytotoxic T cells |
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Autocrine effect |
Acting on the cell that secreted it |
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Paracrine effect |
Acting on nearby cells |
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Endocrine effect |
Enter circulation and axon distant Cell |
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Microbes that affect macrophages and natural killer cells that produce IFN gamma |
Th1 |
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Produce IL 4, 5, 10 for helminths and allergens |
Th2 |
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Functions of cytokines in innate immunity |
Early response to microbes IL-1 IL-6 TNF-alpha INF-alpha INF-beta Acute phase response inflammation, fever, bacterial, viral, parasites |
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Functions of cytokines in adaptive immunity |
IL2,4,5,10, INF gamma Antibody mediated response |
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SCID |
Defective IL2 receptor immunodeficiency |
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Positive selection |
T cells must recognize self MHC antigens or they will die |
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Negative selection |
Presenting T cell with self peptide to make sure it isnt an autoimmune or self reacting T cell |
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How long does the thymocyte maturation process take |
3 weeks as it migrates through cortex to medulla |
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Double negative thymocytes |
Lack cd4 and cd8 Need IL-7 |
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Where does positive and negative selection take place |
In the cortex |
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What does Th1 produce |
INF-gamma and TNF-beta |
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What does Th2 produce |
IL-4, IL-5, IL-10, and IL-13 |
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Functions of cytokines |
Pleiotropic Redundant Synergistic Antagonistic |
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Pleiotropic |
Can act of multiple cells and have multiple functions. |
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Example of pleiotropic |
IL-4 induces Bcell to change isotype to IgE and inhibits action of macros |
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Redundant |
Two or more can have same function |
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Example of redundant |
IL-2, IL-4, IL-5 all induce B proliferation |
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Synergistic |
Combine action is greater than the sum of the actions of a single cytokine |
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Example of synergistic |
INF-gamma and TNF together increase expression of MHC1 |
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Antagonistic |
One had opposite action of other |
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Example of antagonistic |
INF-gamma induce activation of macros while IL-4 inhibits macro activation |
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Three functional categories of cytokines |
Regulate innate immunity regulate adaptive immunity regulate hematopoiesis |
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IL-1 |
Regulate innate immunity Major proinflammatory Induce fever Extracellular catabolism Bone resorption |
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IL-6 |
Innate immunity Produced in response to IL-1 B and T cell activation Acute phase response |
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TNF-a |
Innate immunity T cell activation Regulate expression of MHC II Bacterial, viral,parasitic,tumors |
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IL-4 |
Adaptive B cell activation Isotype switch to IgE Supress Th1 Ab response |
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IL-5 |
Adaptive B cell differentiation Increase Ab secretion Allergies |
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INF-g |
Increase Ag presentation Downreg Th2 Promote NK |
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IL-10 |
Adaptive Down regulate immune response Inhibits IL-2,3, TNFa, INFg |
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IL-7 |
Hematopoiesis Development of T and B cells |
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IL-15 |
Hematopoiesis Development of NK cells |
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IL-3 |
Hematopoiesis Development of myeloid cells |
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G-CSF |
Hematopoiesis Development of neutrophils |
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Th1 produces... |
INF-g |
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Th2 produces... |
IL-4,5,10 Helminths and allergens |
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Growth factor for T cells |
IL-2 |
