Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
36 Cards in this Set
- Front
- Back
Blood Transfusion Reaction |
Type II Hypersensitivity Mechanism= Opsonization (IgG) |
|
Erythrblastosis Fatalis |
Type II Hypersensitivity Reaction Mechanism= Opsonization |
|
Autoimmune Hemolytic Anemia |
Type II Hypersensitivity Reaction Mechanism= Opsonization |
|
Agranulocytosis |
Type II Hypersensitivity Reaction Mechanism= Opsonization |
|
Thrombocytopenia |
Type II Hypersensitivity Reaction Mechanism= Opsonization |
|
Pemphigous Vulgaris |
Type II Hypersensitivity Reaction Mechanism= Complement- Fc receptor -desmosome disruption -blistering
|
|
ANCA Vasculitis |
Type II Hypersensitivity Reaction Mechanism= Complement- Fc receptor -degranulation of neutrophils in muscular wall of epithelium |
|
Goodpasture Syndrome |
Type II Hypersensitivity Reaction Mechanism= Complement- Fc receptor |
|
Hemorrhagic Fever |
Type II Hypersensitivity Reaction Mechanism= Complement- Fc receptor |
|
Myesthenia Gravis |
Type II Hypersensitivity Reaction Mechanism= ADCC |
|
Graves Disease |
Type II Hypersensitivity Reaction Mechanism= ADCC |
|
Systemic Lupus Eryhtematosus |
Type III Hypersensitivity Reaction (systemic) Autoimmune -ANA (anti-dsDNA, anti-Smith antigen) -malar butterfly rash -nephritis -CNS -splenomegaly -Libman-Sacks endocarditis -Pleural effusion -arthritis
|
|
Post-streptococcal Glomerulonephritis |
Type III Hypersensitivity Reaction (systemic) -"planted" streptococcal antigens in the glomerular basement membrane
|
|
Polyarteritis Nodosa Vasculitis |
Type III Hypersensitivity Reaction (systemic) |
|
Reactive Arthritis |
Type III Hypersensitivity Reaction (systemic) |
|
Arthus Reaction |
Type III Hypersensitivity Reaction (localized) -occurs at vaccination site |
|
Multiple Sclerosis |
Type IV Hypersensitivity Reaction |
|
Diabetes Mellitus Tye I (insulitis) |
Type IV Hypersensitivity Reaction |
|
IPEX |
childhood autoimmune disease -FOXP3 mutation -t-regulatory cell dysfunction |
|
ALPS |
childhood autoimmune disease -FasL defect -peripheral tolerance development via activated cell-induced apoptosis is not possible |
|
Sjogren Syndrome |
autoimmune -lymphocytic infiltration of endocrine glands: -salivary--> xerostomia -lacrimal--->xeropthalmia -ANAs: anti-ro (SSA) and anti-la (SSB) indicative of early onset and longer duration -increased risk of lymphoid malignancy -association with ebv, HIV-1, HTLV-1
|
|
Scleroderma |
-autoimmune -anti-topoisomerase (SCL-70)--> systemic -malignant hypertension=> kidneys -anti-cerntromere--> CREST C=calcinosis R=Raynauds Phenomenon E=Esophageal Dysmotility S=Sclerodactyly T= Telangiectasia |
|
Mixed Connective Tissue Disease |
-indicators of SCL, Scleroerma, and polymyositis -high titers of antibodies to RNP -no renal disease -responsive to corticosteroids
|
|
Hypogammaglobulinemia |
-primary immunodeficiency -B cell deficiency -general Ab deficiency -recurrent bacterial infections -higher risk for gastric carcinoma and lymphoma
|
|
Brutons X-Linked Agammaglobulinemia |
-B cell deficiency -x-linked -BtK mutation -inability of B cells to mature from pre-b cells -lack of germinal centers recurrent pyogenic infections -increased risk of colonic carcinoma |
|
Isolated IgA deficiency |
-b cell deficiency -most common primary ID -frequently asymptomatic -prone to GI and sinonasal infections
|
|
DeGeorge's Syndrome (thymic apasia) |
-T cell deficiency -3rd and 4th pharyngeal arch do not develop -lack of thymus and parathyroid -low CD3+ cell counts--> no cell-mediated response -hypocalcemia--> tetany -poor defense against fungal/ viral infections (no CD8) -abnormal facies, congenital heart defects |
|
SCID |
-combined -ADA deficiency (purine synthesis) or common gamma chain mutation (IL-2 receptor) -infants with recurrent severe infections - treatment= bone marrow transplant |
|
Wiskott Aldrich |
-combined -x-linked -cellular defect in actin cytoskeleton/ glycoprotein on B and T cells -thrombocytopenia -reduced lifespan of T cells -pyogenic infections -bleeding -eczema (peri-oral and peri-ocular)
|
|
Hyper IgM Syndrome |
-combined -x-linked -CD40L defect--> no class switching -recurrent bacterial infections -infancy- recurrent respiratory tract bacterial infections, opportunistic infections, recurrent or protracted diarrhea -increased risk for hodgkins lymphoma (EBV) |
|
Chronic Granulomatous Disease |
--x-linked -phagocytic ID -NADPH-oxidase deficiency -recruitment of macrophages and t cells--> granulomas -hepatosplenomegaly and lymphadenopathy -diagnosis= nitroblue tetrazolium
|
|
C3 deficieny |
-increased bacterial infections |
|
C1q, C2, C4 |
-immune-complex- mediated diseases (classical pathway) |
|
C1 esterase inhibitor |
-hereditary angioedema |
|
DAF deficiency |
-paroxysmal nocturnal hemoglobinuria |
|
C5-C9 deficiency |
-nesseiria and meningococcal infections |