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58 Cards in this Set
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Virus families with double stranded DNA
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Herpes
Hepadeno Adeno (Parvo-actually ss) Papova Pox (not Picorna or Paramyxo) |
"Happy"
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Members of Herpes virus family
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Double Stranded, Enveloped, Icosahedral
Herpes simplex Varicella EBV CMV HHV-6 & 8 |
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HSV
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double stranded, enveloped,
dx w/Tzank or immunoflouresc acyclovir (b/c thymadine kinase- also in Varicella) |
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EBV
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double stranded, enveloped
infect B lymphocytes Burkitt's & Nasal Carcinoma Hairy Oral Leukoplakia (in immunocomp'd) splenomegaly & reactive T cells |
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CMV
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double stranded, enveloped
in AIDS & transferred via breast milk Ganciclovir |
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HHV 6 is associated with...
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Roseola
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HHV 8 is associated with...
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Kaposi Sarcoma
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Characteristics of Adenovirus
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double stranded, naked, icosahedral
penton fibers are attachment sites travel & replicate in nodes |
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Characteristics of Papova
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double strand, circular DNA
naked, icosahedral Papilloma virus (HPV) is family member |
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HPV
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member of Papovavirus family
serotype 16 & 18 associated with cervical Ca |
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Characteristics of Pox Virus
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Complex structure
Largest virus linear, ds, DNA, enveloped RNA AND DNA polymerase replicate in cytoplasm |
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members of Pox family
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Variola (small pox)
Molluscum Contagiosum |
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Characteristics of Hepadenavirus
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ds, enveloped DNA
includes HBV |
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Characteristics of Parvovirus
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sm, ss DNA
serotype B19 is the only human pathogen Fifth Disease |
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Fifth Disease
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caused by a Parvovirus
slap cheek rash aplastic crisis w/chronic hemolytic dz- (thalassemia anemia) Hydrops Fetalis |
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RNA Virus Characteristics
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Replicate in Cytoplasm except
influenza & retrovirus Single Stranded except Reo Enveloped except Reo, Calci & Picorna Antisense (neg strand) are all helical, enveloped, ss |
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DNA Virus Characteristics
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Replicate in Nucleus except
Pox Double stranded except Parvo (hepadeno has ss regions) Icosahedral except Pox |
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RNA Virus Families
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Ico, Enveloped, SS
Toga & Flavi Ico, NE, ds- Reo Ico, NE, ss- Picorna & Calci Helical, E, SS- ROBCRAP Rhabdo, Ortho, Bunya, Corona, Arena, Paramyxo Retro |
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Characteristics of Picornavirus
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ss, +RNA, naked
Entero: polio, coxsackie, echo & entero Rhino- common cold (w/adeno) |
PEECRno
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Poliovirus
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member of Picorna
binds Rs in gut & neurons polycistronic (proteases) flaccid paralysis |
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Echovirus
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member of Picorna
throat infections in summer months |
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Coxsackie Virus
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member of Picorna
epidemics in summer & fall may cause meningitis A- "Hand-Foot-Mouth" B- myocarditis |
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Enterovirus
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member of Picornavirus
72 is causative agent for Hep A |
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Rhinovirus
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member of Picorna
causes cold (like adeno) |
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Characteristics of Orthomyxo Family
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-RNA, ss, segmented, enveloped
Influenza A & B |
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Influenza A & B
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members of Orthomyxo family
segmented RNA M (matrix)protein- maturation NM (nucleocapsid) protein Hemagluttin & Neuramidase are targets for immune response B associated with Reyes synd |
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Treatment for influenza
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A- amantadine & rimantadine
A & B- oseltamivir & zamivir |
rifampicin is for MTB
rinitidine is H2 blocker |
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Characteristics of Paramyxovirus
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-RNA, enveloped
initial infection via resp most common cause resp inf in children HN protein (neuraminidase & hemagglutinin)- attachment M protein- inner layer F protein- fusion & hemolytic |
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Members of Paramyxovirus Family
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Parainfluenza- croup
Measles (rubeola) Mumps RSV |
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Parainfluenza Virus
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member of paramyxovirus
causes croup |
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Measles Virus
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member of paramyxovirus
fever & maculopapular exanthem Koplik spots- bluish-white specks on red base in buccal mucosa coryza, conjunctivitis & cough |
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Mumps Virus
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member of Paramyxovirus
vaccine is live attenuated |
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RSV
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member of paramyxovirus
primary cause lower resp inf in infants aerosolized droplets & fomites |
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Characteristics of Togavirus
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+RNA, ss, enveloped
glycoprotein hemagglutinins in envelop |
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Members of Togavirus family
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Alphavirus- EEE & WEE- arthropod-borne, spred via insect vector
Rubivirus (Rubella)- can transmit across placenta |
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Characteristics of Flavivirus
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+RNA, ss, enveloped
similar to Togavirus arthropod-borne |
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Members of Flavivirus family
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Yellow Fever- mosquito
Dengue Fever- mosquito St. Louis encephalitis |
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Yellow Fever
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member of Flavivirus family
mosquito borne hepatitis & hemorrhagic (like dengue) |
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Dengue Fever
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member of Flavivirus Family
mosquito borne hepatitis & hemorrhagic (like yellow) |
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St. Louis Encephalitis
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member of flavivirus family
arthropod borne CNS symptoms |
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Characteristics of Bunyavirus
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-RNA, ss, enveloped
arthrpod vectors |
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members of Bunyavirus
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California Encephalitis
Hanta |
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California Encephalitis
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member of bunyavirus
-RNA, ss, enveloped abrupt fever, bifrontal HA arthropod vector |
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Hanta Virus
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member of Bunyavirus
-RNA, ss, enveloped hemorragic fever & ARDS |
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Characteristics of Rhabdoviruses
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bullet shaped enveloped -RNA
ss nucleocapsid w/glycoprotein spikes replicates in cytoplasm |
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Rabies
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Member of Rhabdovirus
-RNA, bullet shape, envel, ss glycoproteins are immunologic target prodrome, sensory, excitement, paralytic |
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Characteristics of Coronavirus
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+RNA, ss, enveloped
club shaped projections common cold |
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Characteristics of Calcivirus
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+RNA, ss, naked
Norwalk Hep E |
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Characteristics of Calcivirus
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member of calcivirus
+RNA, ss, enveloped gastroenteritis (common cause) epidemics Hep E is very similar |
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Characteristics of Arenaviruses
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segmented, ss, -RNA, enveloped
chronic carrier state Lymphocytic choriomeningitis Lassa |
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Lymphocytic Chroiomeningitis Virus
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Member of Arenovirus
segmented, ss, -RNA, env transmitted by rodents |
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Lassa fever
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member of arenovirus
segmented, +RNA, ss, env rodent high mortality |
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Characteristics of Filoviruses
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-RNA, ss, enveloped
filamentous Marburg & Ebola |
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Marburg
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member of Filovirus
-RNA, ss, enveloped |
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Ebola
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membere of Filovirus
-RNA, ss, enveloped |
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Characteristics of Reovirus
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ds, seg'd RNA, naked
URI & GI Rotavirus- diarrhea in infant Orbivirus- Co Tick Fever |
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Rotavirus
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member of Reovirus
ds, seg'd RNA, naked major cause of diarrhea in infants |
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Characteristics of Retrovirus
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diploid, ss, +RNA, enveloped
2 copies ss RNA reverse transcriptase Pol, Env, Gag proteins HTLV & HIV |
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