Id Board Review 5

Front 1

MOA if azoles

Back 1

Inhibit cytochrome p450, prevent ergosterol synthesis

Front 2

Spectrum of fluconazole

Back 2

Candida, cryptococcus, coccidiodomycosis

Front 3

Candida resistant to fluconazole

Back 3

Maybe: glabrata, guilliermondii, rugosa

Always R: krusei

Front 4

Spectrum of itraconazole

Back 4

Histo, blasto, aspergillus, Candida, coccidio, cryptococcus

Front 5

Spectrum of voriconazole

Back 5

Aspergillus, Candida, scedosporium, fusarium, cryptococcus, histo, blasto, coccidio

Does not cover mucor

Front 6

Spectrum of posaconazole

Back 6

Candida (including krusei), crypto, histo, blasto, coccidio, aspergillus

Also covers mucor

Front 7

Isavuconazole spectrum

Back 7

Aspergillus and mucormycosis

Candida, crypto, histo, blasto, coccidio

Front 8

Echinocandin MOA

Back 8

Beta 1,3 glucan synthase inhibition - prevent cell wall growth

Front 9

Echinocandin spectrum

Back 9

Good for Candida and aspergillus (fungistatic- use as add on or ppx)

Sometimes parapsilosis and guilliermondii are R

Not for crypto, histo, blasto, coccidio

Front 10

Amphotericin MOA

Back 10

Binds to ergosterol, causes depolarization

Front 11

Spectrum of amphotericin

Back 11

Most Candida (except lusitaniae), crypto, blasto, coccidio, histo, most aspergillus (except terreus), and mucor

Front 12

What anti fungal to use in pregnancy

Back 12

Amphotericin

Front 13

Flucytosine MOA

Back 13

Pyrimidine analog, block dna synthesis

Front 14

Spectrum of 5FC

Back 14

Crypto meningitis

Difficult to treat Candida

Front 15

Vaccination for hepb in dialysis patients to

Back 15

Check HbsAb annually and boost if becomes negative

Front 16

When to give tetanus immune globulin

Back 16

Less than 3 vaccinations with dirty wound (clean wound only needs td)

Front 17

Types of extended spectrum beta lactamases

Back 17

TEM, SHV, CTX-M

Front 18

Antifungals with good cns penetration

Back 18

Fluc, vori, ampho, 5FC

Front 19

M184v

Back 19

R lamivudine and emtricitabine, enhances activity of zdv and tdf

Front 20

K65r

Back 20

R all nrti except zdv

Front 21

Gpc clusters, catalase +, coagulase neg

Back 21

Cons, micro coccus, kocuria

Front 22

Gpc in pairs and chains, catalase neg, pyr+, alpha or gamma hemolysis

Back 22

Enterococcus

Front 23

GPC in pairs/chains, catalase neg, pyr +, beta hemolytic

Back 23

Strep pyogenes

Front 24

Gpc in pairs and chains, catalase neg. pyr neg, alpha hemolytic

Back 24

Strep pneumoniae

Front 25

Gpc long chains catalase neg, alpha or gamma hemolysis

Back 25

Step viridans

Front 26

Gpc long chains catalase neg, beta hemolytic

Back 26

Groups B, C, F, G strep

Front 27

Double quotidian fever (q12 hrs) consider

Back 27

Adult stills, visceral leishmaniasis, gonococcal endocarditis, rarely malaria

Front 28

Q fever transmission routes

Back 28

Sheep, goats, cattle, body fluids, infected milk, ticks

Front 29

Treatment of coxiella burnetti endocarditis

Back 29

Doxy plus hydroxychloroquine plus valve removal

Front 30

Clinical syndrome of Q fever

Back 30

Influenza like illness, painless hepatitis, atypical pneumonia,, prolonged fuo, endocarditis

Front 31

Ddx fuo returning traveler

Back 31

Malaria, typhoid fever, acute hiv, kala-azar (leishmaniasis), amebic liver abscess, Tb, brucellosis, meloidosis

Front 32

Ddx asymmetric polyarthritis

Back 32

Dgi, relapsing polychondritis, rheumatic fever, reiters syndrome, psoriatic arthritis, ibd, behcets, whipples disease

Front 33

Treatment of dgi

Back 33

Ctx 1g plus azithro x 5-7 days

Front 34

Treatment gonococcal conjunctivitis

Back 34

Ctx 1 g plus azithro

Front 35

Outpatient treatment of PID

Back 35

Ctx 250mg x1, doxy bid x14 days, +\- flagyl 500mg bid x14 days

Front 36

NTM that can cause disseminated disease

Back 36

Mac, kansasii, abscessus, chelonae, haemophilum

Front 37

Ddx pharyngitis

Back 37

GAS, arcanobacterium, acute hiv, secondary syphilis, gonorrhea, herpes, adenovirus (w/conjunctivitis), HFMD (coxsackievirus), tularemia, fusobacterium

Front 38

Anti-NMDA receptor encephalitis associated with

Back 38

Ovarian teratoma in 50%

Front 39

Skin lesions like mulluscum in a rice farmer from Thailand or India

Back 39

Talaromyces

Front 40

Looks like cns toxo in a patient from Brazil or Chile

Back 40

Consider Chagoma

Front 41

HACEK

Back 41

Haemophilus parainfluenzae

Aggregatibacter actinomycetemcomitans and aphrophilus

Cardiobacterium hominis

Eikenella corrodens

Kingella kingae

Front 42

Treatment strep endocarditis

Back 42

Pcn mic <\= 0.12: pcn or ctx x4w or pcn or ctx plus gent x2 weeks

Pcn mic >0.12 and <0.5: pcn or ctx x4 weeks plus gent for 2 weeks

Pcn mic >0.5: amp plus gent x 6 weeks

Front 43

Treatment nutritionally variant strep endocarditis (abiotropha or granulicatella)

Back 43

Pcn or amp x4 weeks plus gent x2-4 weeks

Front 44

Treatment of staph aureus IE prosthetic valve

Back 44

Mssa: naf/oxa +rifampin x6weeks + gent x2 weeks

Mrsa: vanc + rifampin x6weeks + gent x2 weeks

Front 45

Ddx saddle nose

Back 45

Lepromatous leprosy, syphilis, leishmaniasis, relapsing polychondritis, gpa

Front 46

Q151m

Back 46

R to all nrti except tenofovir

Front 47

Bacterial diarrhea transmitted person to person

Back 47

Salmonella typhi and shigellosis

Front 48

Recent bird exposure, low wbc, horders spots (like rose spots but on the face), headache, splenomegaly

Back 48

Psittacosis

Front 49

NTM hospital associated outbreaks

Back 49

Chelonae, fotuitum, abscessus

Front 50

Weils syndrome

Back 50

Leptospirosis causing renal failure and pulmonary hemorrhage