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10 Cards in this Set
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Neuromuscular Blocking Drugs
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Paralysis/Muscle Relaxation; Facilitate tracheal intubation, improve surgical working conditions, good for mechanical ventilation of lungs, treat laryngospasm; Classified/chosen according or whether Depolarizing (mimics ACh, binds receptor @ muscle and activates receptor) or Non-depolarizing (binds @ receptor and blocks ACh), duration of action (whether long, intermediate or short acting; duration also affected by liver/kidney disease so keep that in mind), speed of onset, side effects, & pathophysiology; Act by interupting transmission of nerve impulses at NMJ of muscles; review in ppt adverse effects of SUX); Note: Int= Intubation Dose, Inf= Infusion
Neuromuscular Blocking Drugs Group 3 |
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Neuromuscular Blocking Drugs
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Neuromuscular-blocking drugs block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles.
|| This is accomplished either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release, or by acting postsynaptically at the acetylcholine receptor. || While there are drugs that act presynaptically (such as botulin toxin and tetrodotoxin), the clinically-relevant drugs work postsynaptically. || Clinically, neuromuscular block is used as an adjunct to anesthesia to induce paralysis, so that surgery, especially intra-abdominal and intra-thoracic surgeries, can be carried out with fewer complications. || Because neuromuscular block may paralyze muscles required for breathing, mechanical ventilation should be available to maintain adequate respiration. || Patients are still aware of pain even after full conduction block has occurred; hence, general anesthetics and/or analgesics must be given to prevent anesthesia awareness. |
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Succinylcholine
Drug (trade name) |
(Anectine)
Neuromuscular Blocking Drugs Group 3 |
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Succinylcholine
Class |
Depolarizing NMBD
Neuromuscular Blocking Drugs Group 3 |
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Succinylcholine
Uses |
Intubation, Paralysis, Laryngospasm
Neuromuscular Blocking Drugs Group 3 |
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Succinylcholine
[ Supplied ] |
20mg/ml
Neuromuscular Blocking Drugs Group 3 |
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Succinylcholine
Dosing--card |
1mg/kg
(1-1.5) Neuromuscular Blocking Drugs Group 3 |
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Succinylcholine
Dosing--Stever |
Int same; Laryngospasm 0.1mg/kg IV
Neuromuscular Blocking Drugs Group 3 |
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Succinylcholine
Caution |
Bradycardia, Hyperalkemia, open globe injury (increases cerebral, intraabdominal and intraoccular pressure)
Neuromuscular Blocking Drugs Group 3 |
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Succinylcholine
Notes |
Onset: 60sec
Duration: 3-5 min Causes Fasciculations Neuromuscular Blocking Drugs Group 3 |
