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Sympathomimetics
Uppers; ↑BP; pt's "tubes" not full b / c haven't eaten, dehydrated, etc., if you vasoconstrict you can increase volume compared to size of tube, inserting ETT raises BP b / c it is a strong stimulus, then BP may drop until next stimulus--surgical incision, so may need to use these until then to keep BP at desired / reasonable rate; Divided into Catecholamines & Synthetic Noncatecholamines; work through activation of α (vasculature--vasocontriction), β1 (heart--↑HR) and / or β2 (lungs--brachial relaxation) receptors--remember this w / mnemonic 1 Heart, 2 lungs for beta receptors

Sympathomimetics
Group 7
Sympathomimetics
Describes a drug that stimulates the sympathetic nervous system or produces physiological effects similar to it
Phenylephrine
Drug
(trade name)
Phenylephrine

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Class
Synthetic non-catecholamine; direct action

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Uses
↑BP, Nasal decongestant (use w / insertion of NA)

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
[ Supplied ]
100mcg / mL

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Dosing--card
100mcg (50-200)

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Dosing--Stever
Bolus 50-100mcg, Inf 0.25-1 mcg / kg / min

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Caution
Increased afterload(heart pumping against high P), Reflex Bradycardia (↑BP but ↓HR)

Sympathomimetics
Vasoactive Drugs
Group 7
Phenylephrine
Notes
binds to α receptors to vasoconstrict "pipe"

Sympathomimetics
Vasoactive Drugs
Group 7