Icp Drugs, Naloxone

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Narcotic Antagonist

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An opioid antagonist is a receptor antagonist that acts on opioid receptors.
A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses.[1] In pharmacology, antagonists have affinity but no efficacy for their cognate receptors, and binding will disrupt the interaction and inhibit the function of an agonist or inverse agonist at receptors.
Antagonists mediate their effects by binding to the active site or to allosteric sites on receptors, or they may interact at unique binding sites not normally involved in the biological regulation of the receptor's activity.

Narcotic Antagonist
Group 5

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Narcotic Antagonist / Opioid antagonists

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Drugs which are competitive antagonists that bind to the opioid receptors with higher affinity than agonists but do not activate the receptors.
This effectively blocks the receptor, preventing the body from responding to opiates and endorphins.

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Naloxone
Drug
(trade name)

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(Narcan)

Narcotic Antagonist
Group 5

Front 4

Naloxone
Class

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Opioid antagonists

Narcotic Antagonist
Group 5

Front 5

Naloxone
Uses

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overdose, resp.
depression, REVERSE OPIOID

Narcotic Antagonist
Group 5

Front 6

Naloxone
[ Supplied ]

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0.4 mg vial

Narcotic Antagonist
Group 5

Front 7

Naloxone
Dosing--card

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20-40-80 mcg (progressive dosing)

Narcotic Antagonist
Group 5

Front 8

Naloxone
Dosing--Stever

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1-4 mcg / kg

Narcotic Antagonist
Group 5

Front 9

Naloxone
Caution

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causes N / V, pain, tachycardia, increased SNS output (all b / c taken away analgesia), DILUTE 0.4mg vial in 10mL and give 1-2ml over 2-3 minutes

Narcotic Antagonist
Group 5

Front 10

Naloxone
Notes

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Quick onset--1min

Narcotic Antagonist
Group 5