Icm Neuro 04: Epilepsy

Front 1

epilepsy is defined as ___ (2) seizures

Back 1

recurrent
unprovoked

Front 2

"recurrent" in epilepsy means at least ___ seizures separated by ___

Back 2

2
24 h

Front 3

T/F: seizures with an identifiable cause constitute epilepsy

Back 3

false

Front 4

seizures with an identifiable cause are called

Back 4

acute symptomatic seizures

Front 5

epilepsy happens becaused of ___ (2) cortical electrical activity

Back 5

increased
synchronized

Front 6

3 causes of epilepsy

Back 6

channelopathy
decreased inhibition
axonal sprouting

Front 7

in one kind of channelopathy, Na+ channel ___ is deficient

Back 7

inactivation

Front 8

channelopathies account for ___% of epilepsy

Back 8

<1

Front 9

in neonates GABA channels are ___

Back 9

excitatory

Front 10

decreased inhibition is more/less of factor in epilepsy than network reorganization

Back 10

less

Front 11

T/F: involuntary movement may be a sign of epilepsy

Back 11

true

Front 12

2 kinds of epilepsy

Back 12

generalized
partial-focal

Front 13

6 kinds of seizures in generalized epilepsy

Back 13

generalized tonic clonic
absence seizure
myoclonic jerk
tonic
clonic
atonic

Front 14

tonic means ___

Back 14

stiff

Front 15

clonic means ___

Back 15

jerking

Front 16

3 kinds of seizure in partial epilepsy

Back 16

partial simple
partial complex
2' generalized tonic-clonic

Front 17

kids mostly get ___ epilepsy
adults mostly get ___

Back 17

half generalized, half partial
partial

Front 18

regions for epileptic foci IDOOF

Back 18

temporal
frontal
parietal
occipital

Front 19

CVA/tumor/trauma usually cause ___ epilepsy

Back 19

partial

Front 20

synchronized firing on interictal EEG has ___ sensitivity and ___ specificity for epilepsy

Back 20

low
high

Front 21

T/F: Pts with only 1 seizure are not always treated for epilepsy

Back 21

true

Front 22

___ is an old drug used for partial seizures

Back 22

carbamazepine

Front 23

___ is an old drug used for generalized seizures

Back 23

valproic acid

Front 24

4 other old antiepileptic drugs

Back 24

barbiturates
hydantoin
benzodiazepine
ethosuxamide

Front 25

5 new antiepileptic drugs
these work for ___ epilepsy

Back 25

lamotrigine
levetiracetam
gabapentin
vigabatrin
topiramate
partial and generalized

Front 26

3 drugs which work on Na+ channel

Back 26

lamotrigine
carbamazepine
hydantoin

Front 27

3 drugs which enhance GABA transmission

Back 27

barbiturates
benzodiazepine
vigabatrin

Front 28

4 drugs for partial epilepsy

Back 28

carbamazepine
lamotrigine
topiramate
levetiracetam

Front 29

3 drugs for generalized epilepsy

Back 29

valproic acid
lamotrigine
topiramate

Front 30

2 drugs available IVly

Back 30

valproic acid
phenytoin

Front 31

___ is teratogenic

Back 31

valproic acid

Front 32

convulsive status epilepticus is ___ minutes of continuous seizure

Back 32

30

Front 33

___% of all epilepsy patients are pharamacoresistant

Back 33

30

Front 34

3 tx for pharmacoresistant pts

Back 34

surgery
ketogenic diet
VNS