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3 Cards in this Set
- Front
- Back
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Pernicious anaemia is seen in what hypersensitivity reaction |
Type 2 |
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Functions of anaphylatoxin |
Anaphylatoxin- C3a, C4a, C5a ●Acts as chemoattractants ●Increase vascular permeability causing Edema |
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Systemic Lupus Erythematosus( everything you know) |
●Autoimmune disease and type 3 hypersensitivity ●Antibodies(IgG) bind DNA and nucleoproteins release from damaged cells(antigen-antibody complex/immune complex) ●The complex is deposited in basement membrane of blood vessels ●Triggers activation of complement system consuming complement proteins around the body (systemic) ●Activated complement proteins cause edema, destruction of vessel wall(cell injury) that triggers inflammation . ●Cell death of vessel cells can result in result of autoantigens (DNA and Nucleoproteins causing cycle to repeat) |
