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10 Cards in this Set
- Front
- Back
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Type 1 hyperlipoproteinemia treatment
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Limit total daily fat intake to no more than 10-25g/day
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Type IIa hyperlipoproteinemia treatment
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-HMG-Co-ARI
-Cholestyramine/colestipol -Niacin |
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Type IIb hyperlipoproteinemia treatment
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-Statins
-Fibrates -Niacin |
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Types III, IV, V treatment
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-Fibrates
-Niacin |
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Niacin MOA
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Reduces VLDL synthesis -> reduces LDL synthesis
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Niacin side effects
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-cutaneous flushing
-hyperuricemia -hyperglycemia -increased LFTs -acanthosis nigricans |
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Concomitant use of what should be avoided at the time of ingestion of niacin due to increased flushing and pruritus
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-alcohol
-hot drinks |
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Bile acid resins MOA
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Stimulates hepatic bile acid synthesis from cholesterol--> increases cholesterol biosynthesis-->increases number of LDL receptors on hepatocyte
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Bile acid resins side effects
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-bloating, flatulence, constipation
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Bile acid resins may aggravate this condition
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hypertriglyceridemia; due to increased hepatic cholesterol biosynthesis paralled by increased VLDL production
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