Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
HD affects what structures most? the ____ which consists of the ____ and the _____, with the latter being affected most significantly
|
certain basal ganglia structures: striatum (putamen + caudate nucleus)--caudate nucleus in particular; nucleus accumbens to a lesser extent
|
|
what is the triad of clinical sxs found in HD (i.e. sxs in these 3 areas)?
|
motor sx, cognitive sx, behavioral sx (to be elaborated in following cards)
|
|
name some of the motor sxs seen in HD
|
involuntary movements (usu. choreiform); unsteady gait (appear intoxicated); abnormalities in eye movements; difficulty with speech and swallowing
|
|
name some bx changes in HD
|
personality change, depression, mood swings
|
|
name some npsych findings in HD when progressed (as with other subcortical dementias): deficits in the domains of ___ and ___, difficulty with the ____ aspect of memory, and ____aphasia
|
executive fxs, attention;
retrieval (recognition mem. rel. preserved); anomic |
|
on what criterion does the dx of HD traditionally rest?
|
emergence of chorea (choreiform movement d/o)
|
|
HD is a (static/progressive) illness that is (lethal/nonlethal) with a usual onset in the __ to __ decades
|
progressive (of course, as a neurodegenerative illness), lethal, 3rd to 5th
|
|
what tx helps to delay onset/slow decline in HD? what tx may help with chorea sxs?
|
there is none presently; antidopaminergic agents
|
|
mood disorders occur in approx(1/4, 1/2, 3/4) of pts with HD
|
1/2
|
|
Huntington Study Group created the HD battery UHDRS, assessing motor, cog, bx and functional sxs. Includes these 3 tests, which are among those that are sensitive to basal ganglia dysfx:
|
Stroop, Digit Symbol, Verbal Fluency
|
|
initial sxs in HD usually include subtle ___ and motor ______, and disturbances in ____
|
chorea, clumsiness, behavior
|
|
common pyschiatric manifestations of HD include _____ disorders, _____ disorder, and/or impulsive or destructive ____-like behavior
|
affective, obs.compulsive, manic
|
|
atrophy of the caudate and putamen in HD can cause the __________ to appear enlarged in MRI or CT scans
|
lateral ventricles
|