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12 Cards in this Set
- Front
- Back
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Types of Inheritance |
Autosomal • Dominant • Recessive • Co-dominant Sex-linked Multi-factorial Mitochondrial |
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Autosomal Genetic Cross |
Back (Definition) |
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Sex-linked genetic cross |
Back (Definition) |
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Human Genetics |
Can’t do crosses |
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Genetic Trait |
No Deleterious Effect |
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Genetic Diseases |
Back (Definition) |
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Inbreeding |
E.g. Haemophilia in royal families Examples: Duchenne Muscular Dystrophy- pedigrees - Enlargement& wasting one muscles - After 20 years- death - 1 in 3500 people have it • Sex-linked recessive Gene -> Gene encoded a protein = Dystrophin -> Lack of Protein |
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Cystic Fibrosis |
1 in 25000 people have it - Airways and lungs get blocked with mucus - Mucus surrounding other cells - Autosomal Recessive Gene - CFTR -> Cell surface transporter protein (Look at photo above) CFTR absent/ not working - No CL2 Ions in extracellular - No water - Build up of mucus |
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Huntington’s Chorea |
- Dominant - Degenerative disease of the nervous system - No obvious phenotype until 35-45 onwards - Mate before they know about the disease - Protein called huntingtin |
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Multifactorial |
Breast cancer - Family of genes that increase susceptibility. BRCA1, BRCA2... - DNA repair enzymes |
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Obesity |
Genetic or environmental? - Genes are responsible - OBS Gene |
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Human genome sequencing project |
2001 - 109 Bases. 40,000-100,000 Genes |
