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17 Cards in this Set
- Front
- Back
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what are the essentials of diagnosis in Hodkin lymphoma?
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painless lymphadenopathy
constitutional symptoms may or may not be present pathologic diagnosis by lymph node biopsy |
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what is the cell of origin in Hodgkin lymphoma?
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germinal center B cell
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what is the age distribution of incidence in HL?
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bimodal age distribution with one peak in young adults (20 to 30 years) and another in older individuals (>55 years)
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what is the rule of thumb for the location of lymphadenopathy in HL?
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young people above the diaphragm
old people below the diaphragm |
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what is the indidence of HL?
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3/100'000
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what is the M:F ratio in HL?
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M:F = 3:2
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what is HL associated with?
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EBV infection confers a 3 fold risk increase
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what are the histologic types and their frequencies in HL ?
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classical HL in 93%, thereof
60% nodular sclerosis 30% mixed-cellularity 5% lymphocyte-rich <1% lymphocyte-depleted lymphocyte-predominant Hodgkin lymphoma (LPHL) in 7% |
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what are the therapy principles in HL?
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isolated radiotherapy for early stage HD with favorable prognostic features
otherwise variable radiotherapy schmemes in combination with chemotherapy |
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what proportion of relapse takes place in the first 2 years and in the first 5 years after therapy?
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two thirds in first 2 years
>90% in first 5 years |
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which organs are adversely affected by which therapy?
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cardiotoxicity due to anthracycline (doxorubicin) and mediastinal irradiation
mnemonic: anthra-C pulmonary toxicity due to bleomycin and irradiation thyroid dysfunction due to irradiation |
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which subtypes of HL confer poorer prognosis?
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lymphocyte depletion subtype
mixed cellularity subtype |
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which subtypes of HL confer better prognosis?
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lymphocyte-predominant form with cure in excess of 70% even with disseminated disease
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what is the (simplified) staging for HL?
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stage I-IV
stage I one lymph node region stage II more than one lymph node region on on side of diaphragm stage III lymph node regions on both sides of diaphragm stage IV disseminated disease with bone marrow or liver involvement stage A, B A= asymptomatic B = B symptoms |
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what are characteristic blood findings in HL?
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lymphocytopenia <1 G/l in one fourth
eosinophilia in one third |
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of what groups of cytostatic drugs are chemotherapy regimens for HD composed of?
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alkylating agents, anthracyclines and steroids
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what are typical chemotherapy regimens for HD?
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ABVD in earlier stages
Adriablastin = doxorubicin Bleomycin Vincristin Dexamethasone in earlier stages BEACOPP escalated Bleomycin Etoposide Adriamycin = doxorubicin Cyclophosphamide Oncovine = vincristin Prednisone Procarbazine in advanced stages |
