Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
31 Cards in this Set
- Front
- Back
Abacavir
|
NRTI: Ziagen
300mg bid, 600mg QD SE-Hypersensitivity, Only NRTI with no renal adjustment |
|
Didanosine
|
NRTI: Videx
>60kg 400mg QD,<60kg 250mg QD TAKE ON EMPTY STOMACH AE: Pancreatitis and peripheral Neuropathy |
|
Emtricitabine
|
NRTI:Emtriva
200mg or 240 mg (24mL) Solution QD AE: Hyperpigmentation (palms/feet) |
|
Lamivudine
|
Epivir
300mg QD or 150 BID Well tolerated |
|
Stavudine
|
Zerit
>60kg: 40mg bid <60kg: 30mg bid AE:Peripheral neuropathy,lipoatrophy |
|
Tenofovir
|
Nucleotide RTI: Viread
300mg QD AE: nephrotoxicity, flatulence |
|
Zidovudine
|
NRTI: Retrovir
300mg bid, 200mg tid AE: anemia, myopaathy Use in pregnant women and neonates, decr. vertical transmission |
|
NRTIs
|
Inhibit reverse transcriptase enzyme by mimicking natural nucleotides.
Black Box warning for Lactic Acidosis SE of fatigue,ha nausea Take with or without food except didanosine |
|
Delavirdine
|
NNRTIs: Rescriptor
Rarely used |
|
Efavirenz
|
Sustiva
600mg QHS AE: Vivid dreams, drowsiness TAKE ON EMPTY STOMACH false +ve canaboid test -ve effect on lipid profile |
|
Etravirine
|
NNRTI: Intelence
200mg BID AE: Rash TAKE WITH FOOD -higher resistance Ci with unboosted PIs |
|
Nevirapine
|
NNRTI: Viramune
200mgQD *14days then 200 BID AE: Rash Hepatotoxicity ( do not use if cd4 >250 F and >400men) ONLY ART initiated at lower dose |
|
NNRTIs
|
Inhibit reverse transcriptase by binding directly to the enzyme.
CYP450 many drug interactions |
|
Protease Inhibitors
|
Take with food to increase tolerability(Nelfinavir to increase absoption)
Increase ther risk of bleeding in pts with hemophilla -Associated with long term metabolic effects ( triglycerides, blood glucose, and fat redistribution (lipodystrophy)) -Inhibitors of CYP3A4 except tipranavir which is an inducer -With PDE5 need to decr, dose and interval - sulfa moiety in fosamprenavir, darunavir, and tipranavir be aware of sulfonamide allergy |
|
Atzanavir
|
PI: Reyataz
400mg QD or 300mg w 100RTV QD AE: Hyperbilirubinemia, Nephrolithiasis (kidney stones) DI: antacids- 2hrs before or 1 hr after atzanavir, H2-blocker= simultaneously or <10hr after boosted atzanavir, PPI+ not recommended in tx experienced pts. Max dose = 20mg qd of prilosec 12 hrs before /after -Increase fluid intake to risk of nephrolithiasis |
|
Darunavir
|
Prezista
800mg + RTV100 QD pt naive only 600mg +RTV100 BID |
|
Fosamprenavir
|
PI: Lexiva
1400mg bid or 1400mg + RTV 100-200 mg QD (Pt naive only) 700mg+ RTV100 BID |
|
Indinavir
|
Crixivan
800mg +RTV 100-200 BID AE: Hyperbilirubinemia , nephrolithiasis |
|
Lopinavir/ritinovir
|
PI: Kaletra
200/50 or 100/25 2tabs bid or 4 tabs qd (pt naive only) |
|
Nelfinavir
|
PI: Viracept
1250mg bid, 750 tid ONlY PI that cannot be boosted with RTV |
|
Ritinovir
|
PI:Norvir
100-200 mg with other PIs AE: Gastrointestinal, lipid effects -used to inhibit metabolism of other PIs(cyp3A4 inhibitor) |
|
Saquinavir
|
Invirase
1000mg with 100mg RTV bid |
|
Tipranavir
|
Aptivus
500mg with RTV200mg bid CYP3A4 inducer therefore given with a higher dose of RTV |
|
Maraviroc
|
CCR5:
Selzentry 150-600mg BID AE: Rash, Cough fever, Hepatotoxicity Testing for tropism assay required beforeinitiation |
|
Enfuvirtide
|
Fusion Inhibitor
Fuzeon 90mg SC BID AE: Injection site rxn unused doses can be refrigerator (use within 24hrs) |
|
Raltegravir
|
Integrase inhibitor
Isentress 400mg bid AE: usually well tolerated, CPK elevation, nausea, HA with Rifampin increase to 800mg BID |
|
Zidovudine and Lamivudine
|
Combivir
300/150 mg BID |
|
Zidovudine, Lamivudine, and abacavir
|
Trizivir
300/150/300 mg BID |
|
Lamivudine and abacavir
|
Epzicom
300/600 mg QD |
|
Tenofovir, emtricitabine, efavirenz
|
Atripla
300/200/600 QHS |
|
Tenofovir, emtricitabine
|
Truvada
300/200 mg QD |