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143 Cards in this Set

  • Front
  • Back
Tissues:
collections of cells/cell products performing specific, unified functions (histology)
Epithelial:
cover exposed surfaces; line internal passageways; form glands
Connective:
protect/support body, organs; bind organs together; store energy; immunity
Muscular:
generates physical force
Nervous:
detect changes inside & outside body; initiate & transmit nerve impulses
Epithelium can be 2 types:
1. Covering & lining: skin; organ coverings; line cavities, CV/resp/GI/urinary/repro systems; ducts
2. Glandular: secreting portion
Epithelial Tissue: Functions
1.
2.
3.
Protection
Secretion/absorption
Permeability
General Epithelial Features: PACAR
1) Polarity: apical, basal surfaces
2) Attachment: to basement membrane
3) Cellularity: tightly packed, cell junctions
4) Avascularity
5) Regeneration: cell division
Covering & Lining Epithelium is Classified by arrangement of ___.
cell layers
Covering & Lining Epithelium
Simple must be:
Pseudo-stratified helps:
Stratified Must be:
1. MUST BE PERMEABLE diffusion, osmosis, filtration, secretion, absorption
2.HELPS STUFF MOVE often ciliated, mucus
3. MUST BE TOUGH
protects underlying tissue from wear & tear
Covering & Lining Epithelium
Also classified by cell shape
1.
2.
3.
Covering & Lining Epithelium
Squamous must be:
MUST BE PERMEABLE
thin, allows substances to pass through them
Covering & Lining Epithelium
Cuboidal cells act as the ___: ___,___
EXCHANGE CENTER secretion, absorption
Covering & Lining Epithelium
columnar cells as the 2nd ___: also ___. ___
EXCHANGE CENTER 2 secretion, absorption
Epithelial Cells Connections: Cell Adhesion Molecules
Tight Junctions:
1. Prevent passage of ___, solutes.
2. Isolates substance in lumen
Prevent passage of H2O, solutes
Isolates substance in lumen
Epithelial Cells Connections: Cell Adhesion Molecules

Gap Junctions
1. Allows ___to pass
2. Coordinate ___contractions
Gap Junctions
Allows ions to pass
Coordinate heart contractions
Epithelial Cells Connections: Cell Adhesion Molecules

Desmosomes
1. ___cells together
2. Allow ___&___
Desmosomes
Ties cells together
Allow bending & twisting
Epithelial Cells Connections: Cell Adhesion Molecules
Hemidesmosomes
1. Attach to ___membrane
Hemidesmosomes
Attach to basement membrane
Simple Squamous Epithelium
Locations:
Functions:
Simple Cuboidal Epithelium
Locations:
Functions:
Simple Columnar Epithelium
Location:
Function:
Pseudostratified Columnar Epithelium
Locations:
Functions:
Stratified Squamous Epithelium
Locations:
Functions:
Stratified Cuboidal Epithelium
Locations:
Functions:
Stratified Columnar Epithelium
Locations:
Functions:
Transitional Epithelium
Locations:
Functions
Glandular Epithelium
2 types of glands:
1. ___: substances enter extracellular fluid and into bloodstream without flowing thru ducts
-Pituitary, thyroid, adrenal
2. ___: substances enter ducts that empty at surface of covering or lining epithelium
-Sweat, salivary, mammary
1. Endocrine: substances enter extracellular fluid and into bloodstream without flowing thru ducts
-Pituitary, thyroid, adrenal
2. Exocrine: substances enter ducts that empty at surface of covering or lining epithelium
-Sweat, salivary, mammary
Exocrine Glandular Features
Structure
1. Unicellular:
2. Multicellular:
Structure
1. Unicellular: individual secretory cells
2. Multicellular: organs w/ glandular epithelium
Exocrine Glandular Features
Secretions
1. Serous: watery, contains ___.
-Parotid salivary glands
2. ___: mucins + water = mucus
--Sublingual salivary glands
3. ___: 1+ types of gland cells, 2 secretions
--Submandibular salivary glands
Secretions
Serous: watery, contains enzymes
Parotid salivary glands
Mucous: mucins + water = mucus
Sublingual salivary glands
Mixed: 1+ types of gland cells, 2 secretions
Submandibular salivary glands
Exocrine Modes of Secretion:
1. Merocrine
2. Apocrine
3. Holocrine
1. Merocrine
2. Apocrine
3. Holocrine
Exocrine Modes of Secretion
Merocrine:
Release via exocytosis
Most common
Exocrine Modes of Secretion:
Apocrine:
Loss of both product and cytoplasm
Exocrine Modes of Secretion
Holocrine:
Cell fills with product, bursts to release
Gland cells replaced by stem cells
Structural Classes of Exocrine Glands
SIMPLE GLANDS vs COMPOUND GLANDS
Connective Tissue Functions
Structural framework
Transport ___, dissolved ___
Protect delicate ___
Supporting/surrounding/interconnecting
Energy ___
Defend from ___
Structural framework
Transport fluids, dissolved materials
Protect delicate organs
Supporting/surrounding/interconnecting
Energy reserves
Defend from microorganisms
Connective Tissue
Most ___tissue type!
Found btwn other ___, hence the name
Most common tissue type!
Found btwn other tissues, hence the name
Connective Tissue
Consists of small cells far apart in lots of ___material (___)
Consists of small cells far apart in lots of extracellular material (matrix)
Connective Tissue
Matrix = ___fibers + ___substance
--Secreted by cells, determines tissue ___.
--Matrices from cells as diverse as cells themselves
Matrix = protein fibers + ground substance
Secreted by cells, determines tissue qualities
Matrices from cells as diverse as cells themselves
Connective Tissue
Good ___supply (well vascularized)
Exception: cartilage is avascular
Good blood supply (well vascularized)
Exception: cartilage is avascular
Connective Tissue Elements:
1.
2.
3.
Cells, Matrix protein fibers, Matrix ground substance
Connective Tissue Elements:
Cells
Provide:
structure, immune function, energy storage
Connective Tissue Elements:
Matrix protein fibers
1. Produced by ___ ___ cells
2. C___, e___, r___
3. Give structure, flexibility, elasticity, strength
Matrix protein fibers
1. Produced by connective tissue cells
2. Collagen, elastic, reticular
3. Give structure, flexibility, elasticity, strength
Connective Tissue Elements:
Matrix ground substance
1. Secreted by ___ ___ cells
2. Can be ___, ___, ___(H2O + organic molecules)
3. Affects how tissues develop, migrate, proliferate, change shape, function, etc.
Matrix ground substance
1. Secreted by connective tissue cells
2. Can be liquid, gel, solid (H2O + organic molecules)
3. Affects how tissues develop, migrate, proliferate, change shape, function, etc.
Connective Tissue Classes:
1.
2.
3.
Connective Tissue Elements: Protein Fiber Types
1.
2.
3.
1. Collagen fibers
2. Reticular fibers
3. Elastic fibers
Connective Tissue Elements: Protein Fiber Types
Collagen fibers (e.g., tendons, ligaments)
1. Most ___connective fiber
2. Long, straight, ___, ___
3. Resists force in ___ direction
Collagen fibers (e.g., tendons, ligaments)
1. Most common connective fiber
2. Long, straight, STRONG, FLEXIBLE
3. Resists force in 1 direction
Connective Tissue Elements: Protein Fiber Types Reticular fibers (e.g., sheaths around organs)
1. Network of interwoven fibers (___)
2. Strong, flexible, resists force in ___directions
3. Stabilizes ___cells (___), structures
Reticular fibers (e.g., sheaths around organs)
1. Network of interwoven fibers (stroma)
2. Strong, flexible, resists force in many directions
3. Stabilizes functional cells (parenchyma), structures
Connective Tissue Elements: Protein Fiber Types Elastic fibers (e.g., aorta)
1. ___& ___to original position; wavy
Elastic fibers (e.g., aorta)
1. Stretch & return to original position; wavy
Mesenchymal:
stem cells for all connective tissues
CTP
Fibroblasts:
most abundant, secrete hyaluronan & proteins to make GS viscous
CTP
Melanocytes:
melanin-releasing cells in skin CTP
Adipocytes:
fat cells CTP
Macro/microphages:
scavenge pathogens, damaged cells, respond to injury/infection CTP
Mast:
release histamine, heparin--> inflammation CTP
Lymphocytes:
defend body, respond to damage CTP
Connective Tissue Proper: Loose (“packing peanuts”)
1.
2.
3.
1. Areolar
2. Adipose
3. Reticular
Connective Tissue Proper:

Areolar
1. Many cell ___, all ___, open ___
2. Near ___, part of ___tissue
Areolar
1. Many cell types, all fibers, open framework
2. Near epithelia, part of subcutaneous tissue
Connective Tissue Proper:
Adipose
1. Adipocytes, which hold ___ droplets
2. Found w/ ___tissue; energy, protects ___
Adipose
1. Adipocytes, which hold TG droplets
2. Found w/ areolar tissue; energy, protects organs
Connective Tissue Proper:
Reticular
1. ___fibers & cells
2. Forms ___ for lymph organs (spleen, lymph nodes, marrow), liver, kidneys; filtration
1. Reticular fibers & cells
2. Forms mesh scaffold for lymph organs (spleen, lymph nodes, marrow), liver, kidneys; filtration
Connective Tissue Proper: ___ ___
Connective Tissue Proper: Loose Adipose
Connective Tissue Proper: ___ ___
Connective Tissue Proper: Loose Reticular
CTP Dense-Types:
1.
2.
3.
4.
Regular
Irregular
Elastic
Dense regular
CTP Dense-Types:
Regular
1. Contains ___ collagen pattern, fibroblasts
2. Ligaments, tendons
Regular
Contains parallel collagen pattern, fibroblasts
Ligaments, tendons
CTP Dense-Types:
Irregular
1. Contains ___collagen pattern, fibroblasts
3. ___, ___valves, membranes, ___
1. Contains irregular collagen pattern, fibroblasts
3. Dermis, heart valves, membranes, joints
CTP Dense-Types:
Elastic
1. Dense ___+ elastic fibers, fibroblasts
2. ___tissue, ___walls, vertebral ligaments
Elastic
1. Dense regular + elastic fibers, fibroblasts
2. Lung tissue, artery walls, vertebral ligaments
Connective Tissue Proper: Dense Regular
Locations:
Functions
Connective Tissue Proper: Dense Irregular-
Locations:
Functions:
INTERWOVEN NETWORKS OF COLLAGEN FIBERS
Layered in skin, perichondrium, periosteum, some organ capsules
Connective Tissue Proper: Dense Elastic
Locations:
Functions:
Connective Tissue Proper: Fasciae
Connective Tissue Framework
1.
2.
3.
Fluid Connective Tissues
Types
1
2
Blood
Lymph
Fluid Connective Tissues
1. Blood
--Cells: ___,___,___
--Fluid matrix: ___(proteins are dissolved)
1. Blood
--Cells: RBCs, WBCs, platelets
--Fluid matrix: plasma (proteins are dissolved)
Fluid Connective Tissues
Lymph
1. Cells: some ___
--Fluid matrix: ___(proteins are dissolved)
--Plasma -> ___fluid -> lymph
Lymph
1. Cells: some WBCs
--Fluid matrix: lymph (proteins are dissolved)
--Plasma -> interstitial fluid -> lymph
Fluid Connective Tissues
Blood and Lymph
Supporting Connective Tissues
1. Less ___cell population
2. Dense ___ ___
Closely packed ___
Less diverse cell population
Dense ground substance
Closely packed fibers
Supporting Connective Tissues
2 types:
Cartilage
Bone
Supporting Connective Tissues Cartilage-
Gel-type ground substance
Shock absorption, protection
Supporting Connective Tissues
Bone-
Calcified ground substance (rigid w/ mineral salts)
Support, protection, mineral storage, R(W)BC formation
SCT-Cartilage
1. Connective tissue structure
--Cells: ___
--Matrix protein fibers: ___(and/or ___)
--Matrix GS: proteoglycans from ___sulfate
1. Connective tissue structure
--Cells: chondrocytes
--Matrix protein fibers: collagen (and/or elastic)
--Matrix GS: proteoglycans from chondroitin sulfate
SCT-Cartilage
1. Avascular
--___secrete ___factors
1. Avascular
--Chondrocytes secrete antiangiogenic factors
SCT-Cartilage
1. ___
--Membrane layer of dense irregular tissue
--Outer fibrous layer: ___producing collagen
--Inner ___layer: becomes –blasts, -cytes
1. Perichondrium
--Membrane layer of dense irregular tissue
--Outer fibrous layer: fibroblasts producing collagen
--Inner chondrogenic layer: becomes –blasts, -cytes
Supporting Connective Tissue: Cartilage—Perichondrium
Supporting Connective Tissue: Cartilage—Perichondrium
Supporting Connective Tissue: Cartilage—Types
1.
2.
3.
1.Hyalin
2.Elastic
3.Fibrocartilage
Supporting Connective Tissue: Cartilage—Types
Hyaline:
flexible, shock absorber, weakest
--Translucent matrix, fine (invisible) collagen fibers
--Ends of bones, nose, fetal skeleton
Supporting Connective Tissue: Cartilage—Types
Elastic:
maintain shape
--Tightly packed elastin threads (hairy appearance)
--External ear, eustachian tubes, epiglottis
Supporting Connective Tissue: Cartilage—Types Fibrocartilage:
rigid, strong
Very densely bundled collagen fibers
--Sparse cell distribution
--Knees, between vertebrae
Supporting Connective Tissue: Hyaline Cartilage
Location:
Function:
Supporting Connective Tissue: Elastic Cartilage
Location:
Function:
Supporting Connective Tissue: Fibrocartilage
Location:
Function:
STC: Cartilage—Growth
Interstitial growth
Chondrocytes in matrix divide, produce additional matrix
SCT: Cartilage—Growth
Appositional growth
Perichondrium divides, cartilage grows by adding to outer layer
SCT: Bone (Osseus Tissue)
Cell types:
1. Osteocytes-
2. Osteoblasts-
3. Osteoclasts-
1. Osteocytes maintain mineral content
2. Osteoblasts produce fibers/matrix
3. Osteoclasts dissolve fibers/matrix
SCT: Bone (Osseus Tissue)

Mineralized matrix
Organic: ___
Inorganic ___
Mineralized matrix
Organic: 35%
Inorganic 65%
SCT: Bone (Osseus Tissue)
2 classifications:
1. Compact
2. Cancellous (or “spongy”; not shown)
Supporting Connective Tissue: Cartilage vs. Bone
Muscle Tissue
Three types:
Three types
Skeletal
Cardiac
Smooth
Skeletal Muscle Tissue
Location:
Function:
Cardiac Muscle Tissue:
Locations:
Functions:
Smooth Muscle Tissue
Location:
Function:
Nervous Tissue
Body Membranes:
1.
2.
3.
4.
Body Membranes:
1. Mucus m.:
2. Serous m.:
3. Synovial m.:
4. Cutaneous m.:
c
Mucus m.:
Mucus m.: connective, epithelial
Line GI, respiratory, urinary, reproductive tracts
Moisture reduces friction; promotes absorption
Body Membranes:
Serous m.:
connective, epithelial
Line closed cavities & surround organs
Reduce friction, parietal vs. visceral
Pleural, pericardium, peritoneum
Body Membranes:
Synovial m.:
connective
Line joint cavities, synovial fluid to reduce friction
Body Membranes:
Cutaneous m.:
connective, epithelial (SKIN!)
The Integumentary System
___system of the body
Largest system of the body
The Integumentary System
"Cutaneous membrane”
___: outer
___: inner
Cutaneous membrane”
Epidermis: outer
Dermis: inner
The Integumentary System
Accessory structures
___, ___,___
Accessory structures
Hair, nails, glands
The Integumentary System
Subcutaneous layer (___)
___tissue, ___tissue
Subcutaneous layer (hypodermis)
Adipose tissue, areolar tissue
The Integumentary System
Functions
1.P
2.E
3.T
4.N
5.V
6.S
Protective barrier
Excretion
Thermoregulation
Nutrient storage (adipose)
Vitamin D3 synthesis
--UV light
Sensory detection
--Touch, pressure, pain, temp
The Integumentary System: Components
Skin Layers: Epidermis—protective Cell Make up
1.
2.
3.
4.
Cell Make up
1. Keratinocytes
2. Melanocytes
3. Langerhans cells
4. Merkel cells
Skin Layers: Epidermis—
Keratinocytes:
90% of epidermis
Make keratin (protective, waterproof)
Skin Layers: Epidermis— Melanocytes:
8% of epidermis
Make melanin, transfer to keratinocytes
Skin Layers: Epidermis—Langerhans cells
Immune response
Skin Layers: Epidermis—
Merkel cells
Detect touch, pressure
Skin Layers: Epidermis—
1. Mechanical ___
2. Prevents ___
3. Defense against ___
4. ___(nutrients diffuse in from dermis)
1. Mechanical protection
2. Prevents fluid loss
3. Defense against microorganisms
4. Avascular (nutrients diffuse in from dermis)
Skin Layers: Epidermis—
Skin Layers: Epidermis—
Skin Layers: Epidermis—Stratum Basale
1. ___layer
1. Deepest layer
Skin Layers: Epidermis—Stratum Basale
Cells:
1. Basal (___) cells
2. Melanocytes
3. Merkel cells (___)
Cells divide, push up & interlock (___)
Cells:
1. Basal (stem) cells
2. Melanocytes
3. Merkel cells (glabrous)
Cells divide, push up & interlock (stability)
Skin Layers: Epidermis—Stratum Basale
Epidermal ridges (___. ___)
Skin Layers: Epidermis—Stratum Basale
Skin Layers: Epidermis—Stratum Basale
Skin Layers: Epidermis—Stratum Granulosum
Skin Layers: Epidermis—Stratum Lucidum
1. Not in most skin
2. Areas of constant ___
--___, ___
3. Translucent layer
4. Cells flattened, packed close together
Stratum Lucidum
1. Not in most skin
2. Areas of constant Pressure
--Soles, palms
3. Translucent layer
4. Cells flattened, packed close together
Skin Layers: Epidermis—Stratum Corneum
1. “___” surface
2. ___cells shed
3. Discourages ___
4. Water ___
--Lose or gain water slowly
300-400 mL/day vs3-4 L/day
Stratum Corneum
1. “Exposed” surface
2. Dead cells shed
3. Discourages microbes
4. Water resistant
--Lose or gain water slowly
300-400 mL/day vs3-4 L/day
Skin Layers: Epidermis and Water Movement
1. Hydration (water ___)
From immersion in ___soln (osmosis)
Causes stretching & ___of skin
2. Dehydration (water ___)
Damage to stratum ___(burns, blisters)
Immersion in ___soln (osmosis)
3. Insensible perspiration
Interstitial fluid ___thru stratum ___
4. Sensible perspiration
Water ___by sweat glands in ___
1. Hydration (water gain)
From immersion in hypotonic soln (osmosis)
Causes stretching & wrinkling of skin
2. Dehydration (water loss)
Damage to stratum corneum (burns, blisters)
Immersion in hypertonic soln (osmosis)
3. Insensible perspiration
Interstitial fluid evaporated thru stratum corneum
4. Sensible perspiration
Water excreted by sweat glands in dermis
Skin Layers: Epidermis and Vitamin D
1. 7-___--> ___
Pre-vitamin D3 --> ___vitamin D3
--Conversion requires ___radiation
1. 7-Dehydrocholesterol --> cholecalciferol
Pre-vitamin D3 --> inactive vitamin D3
--Conversion requires UV radiation
Skin Layers: Epidermis and Vitamin D
1. ___, ___convert into calcitriol
1. Liver, kidneys convert into calcitriol
Skin Layers: Epidermis and Vitamin D
Insufficient vitamin D3
1. ___(children)
2. ___(adults)
Insufficient vitamin D3
1. Rickets (children)
2. Osteomalacia (adults)
Skin Layers: Epidermis and EGF
1. ___ ___ ___(EGF)
--Powerful ___growth factor
--Produced by ___& duodenal glands
--Used to grow skin ___
1. Epidermal Growth Factor (EGF)
--Powerful peptide growth factor
--Produced by salivary & duodenal glands
--Used to grow skin grafts
Skin Layers: Epidermis and EGF
1. Functions:
--Promotes division of ___cells
--Accelerates ___production
--Stimulates ___repair
--Stimulates ___secretions
Skin Layers: Epidermis and EGF
1. Functions:
--Promotes division of germinative cells
--Accelerates keratin production
--Stimulates epidermal repair
--Stimulates glandular secretions
Skin Layers: Dermis—Circulation
Skin Layers: Dermis
Skin Layers: Dermis—Nerves
1. ___nerves
--Blood flow
--Gland secretions
2. ___nerves
--Meissner corpuscles
Light touch—”tactile corpuscles”
--___corpuscles
Deep pressure—”lamellated corpuscles”
--___nerve endings
Temperature, pain, itch, tickle
Skin Layers: Dermis—Nerves
1. Autonomic nerves
--Blood flow
--Gland secretions
2. Sensory nerves
--Meissner corpuscles
Light touch—”tactile corpuscles”
--Pacinian corpuscles
Deep pressure—”lamellated corpuscles”
--Free nerve endings
Temperature, pain, itch, tickle
Skin Layers:
Skin Layers:
Skin Layers: Hypodermis“___”
1. Continuation of loose CT below ___
2. Adipose, areolar
___ skin against underlying organs
Hypodermis“Subcutaneous”
1. Continuation of loose CT below dermis
2. Adipose, areolar
Stabilized skin against underlying organs
Skin Accessory Structures: Hair
1. ___
2. Everywhere except ___ skin
--Palms, soles, lips
3. Dead, ___epidermal cells
--Shaft, root, bulb
Arrector pili, oil glands
1. Protective
2. Everywhere except glabrous skin
--Palms, soles, lips
3. Dead, keratinized epidermal cells
--Shaft, root, bulb
Arrector pili, oil glands
Skin Accessory Structures: Hair
1. Vellus (peach fuzz)
2. Terminal hairs (heavy)
3. Club hair
--Cessation of growth
--Hair growth cycle
4. Color, texture
a. Genetic
b. Environmental
c. Hormonal
1. Vellus (peach fuzz)
2. Terminal hairs (heavy)
3. Club hair
--Cessation of growth
--Hair growth cycle
4. Color, texture
a. Genetic
b. Environmental
c. Hormonal
Skin Accessory Structures:
1. Hair Internal & external root sheaths
2. Cuticle, cortex, medulla of hair
3. Base of follicle: ___
--___ active source of cells
1. Hair Internal & external root sheaths
2. Cuticle, cortex, medulla of hair
3. Base of follicle: bulb
--Mitotically active source of cells
Skin Accessory Structures: Glands Sebaceous
Skin Accessory Structures: Glands Apocrine and Merocrine
Skin Accessory Structures: Nails
1. Plates of hard-packed dead ___cells
2. Nail body:___
3. Free edge: ___
4. Root: ___
1. Plates of hard-packed dead keratinized cells
2. Nail body: visible portion
3. Free edge: what you trim
4. Root: form new nail cells deep to this
Injury & Repair
Regenerates easily: 1) ___, 2) ___, 3) ___
Regenerates easily: 1) Scab, 2) Granulation, 3) Scar
Injury & Repair
Injury & Repair
Skin Functions: Thermoregulation
1. ___
--Evaporative cooling in the heat
--Works better in ___ climates
2. Vasodilation
--As body temp ___, skin blood vessels ___, allow more blood to give off heat
3. Vasoconstriction
--As body temp ___, skin blood vessels ___, allow less blood to give off heat
1. Sweat
--Evaporative cooling in the heat
--Works better in dry climates
2. Vasodilation
--As body temp rises, skin blood vessels dilate, allow more blood to give off heat
3. Vasoconstriction
--As body temp falls, skin blood vessels constrict, allow less blood to give off heat